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Dilution Information

Rabbit Lamin-B1 Monoclonal Antibody | anti-Lamin-B1 antibody

Lamin-B1 (RBT-LMNB1)

Reactivity
Human, Mouse, Rat
Synonyms
Lamin-B1; Monoclonal Antibody; Lamin-B1 (RBT-LMNB1); lamin-b1; lamin b1; lmnb1; lmn-b1; anti-lamin-b1; anti-lamin b1; anti-lmnb1; anti-lmn-b1; anti-Lamin-B1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-LMNB1
Form/Format
Paraffin, Frozen
Lamin-B1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human Lamin-B1 protein.
Control
Colon, Breast, Fallopian Tube, Tonsil, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma, Colon Adenocarcinoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)

Dilution Information

Dilution Information

Immunohistochemistry (IHC)

(Lamin-B1 Antibody Immunohistochemistry on an FFPE Colon Adenocarcinoma Tissue)

Immunohistochemistry (IHC) (Lamin-B1 Antibody Immunohistochemistry on an FFPE Colon Adenocarcinoma Tissue)
Related Product Information for anti-Lamin-B1 antibody
Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type Lamin along with A-type Lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation.
Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer. It has been observed that Lamin-B1 levels are reduced in Lung Cancer patients compared to normal Lung tissue and that lower expression of Lamin-B1 antibodywas associated with higher tumor grade. The levels of lamin A, on the other hand, were not altered in human Lung Tumors, indicating that the different types of lamins have distinct functions in lung carcinogenesis. Overexpression of Lamin-B1 antibody can also indicate poor prognosis in Colon and Pancreatic Cancers.

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Product Notes

The Lamin-B1 (Catalog #AAA370501) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Lamin-B1 (RBT-LMNB1) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Lamin-B1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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