Dilution Information
Rabbit anti-Human ICOS/CD278 Monoclonal Antibody | anti-ICOS/CD278 antibody
ICOS/CD278 (RM417)
Reactivity
Human
Synonyms
ICOS/CD278; Monoclonal Antibody; ICOS/CD278 (RM417); icos; into-icos; cd278. anti-cd278; t-cell costimulatory molecule; anti-ICOS/CD278 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM417
Form/Format
Paraffin, Frozen
ICOS is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
ICOS is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues near the C-terminus of the human ICOS protein.
Control
Colon, Tonsil, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma
Localization
Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(ICOS Antibody Immunohistochemistry on an FFPE Tonsil Tissue)
Immunohistochemistry (IHC)
(ICOS Antibody Immunohistochemistry on an FFPE Tonsil Tissue)
Related Product Information for anti-ICOS/CD278 antibody
CD278 is also known as inducible T-cell costimulatory molecule (ICOS). CD278 is homologous to the CD28/CTLA-4 proteins and is expressed on activated T cells and unstimulated thymocytes. CD278 plays a major role in regulation of cell-cell signaling, adaptive immune response, and cell proliferation. Interaction of CD278 and its ligand ICOS-L results in increased production of interleukins, which promote differentiation of Tfh and Tregs and development of Th1, Th2, and Th17 cells.
CD278/ICOS-L interaction has been shown to promote either antitumor T cell response or pro-tumor responses when triggered in Tregs (such as in Multiple Myeloma, Acute Myeloid Leukemia, and some invasive Breast Carcinomas). Therefore, both agonistic and antagonistic monoclonal antibodies targeting this pathway can be potential cancer immunotherapy.
ICOS antibody is primarily expressed on activated CD4+ and CD8+ T cells where it regulates immune responses and plays a role in the regulation of T Follicular helper cells. ICOS antibody is a sensitive marker for identifying T cell Lymphomas of Follicular Helper T cell origin, especially certain patterns of Angioimmunoblastic T-cell lymphoma (AITL) and Peripheral T-cell lymphomas with T-follicular Helper Phenotype (PTCL-TFH). This is becoming increasingly important given WHO 2016 test guidelines. Immunohistochemical analysis revealed that ICOS is widely expressed by malignant cells in skin biopsy specimens from patients with Mycosis Fungoides and Sézary syndrome (SS), as well as involved in node biopsy specimens from patients with SS.
CD278/ICOS-L interaction has been shown to promote either antitumor T cell response or pro-tumor responses when triggered in Tregs (such as in Multiple Myeloma, Acute Myeloid Leukemia, and some invasive Breast Carcinomas). Therefore, both agonistic and antagonistic monoclonal antibodies targeting this pathway can be potential cancer immunotherapy.
ICOS antibody is primarily expressed on activated CD4+ and CD8+ T cells where it regulates immune responses and plays a role in the regulation of T Follicular helper cells. ICOS antibody is a sensitive marker for identifying T cell Lymphomas of Follicular Helper T cell origin, especially certain patterns of Angioimmunoblastic T-cell lymphoma (AITL) and Peripheral T-cell lymphomas with T-follicular Helper Phenotype (PTCL-TFH). This is becoming increasingly important given WHO 2016 test guidelines. Immunohistochemical analysis revealed that ICOS is widely expressed by malignant cells in skin biopsy specimens from patients with Mycosis Fungoides and Sézary syndrome (SS), as well as involved in node biopsy specimens from patients with SS.
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Product Notes
The ICOS/CD278 (Catalog #AAA370497) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ICOS/CD278 (RM417) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "ICOS/CD278, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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