Dilution Information
Mouse anti-Human MNDA Monoclonal Antibody | anti-MNDA antibody
MNDA (BSB-157)
Reactivity
Human
Synonyms
MNDA; Monoclonal Antibody; MNDA (BSB-157); anti-mnda; Myeloid cell Nuclear Differentiation Antigen; anti-Myeloid cell Nuclear Differentiation Antigen; anti-MNDA antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-157
Form/Format
Paraffin, Frozen
MNDA is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
MNDA is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the C-terminus of the human MNDA protein.
Control
Breast, Colon, Fallopian Tube, Brain, Tonsil, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(MNDA Antibody Immunohistochemistry on an FFPE Diffuse Large B Cell Lymphoma Tissue)
Immunohistochemistry (IHC)
(MNDA Antibody Immunohistochemistry on an FFPE Diffuse Large B Cell Lymphoma Tissue)
Related Product Information for anti-MNDA antibody
Myeloid cell Nuclear Differentiation Antigen (MNDA) is present in granulocytes and monocytes (myeloid and B cells), found in the marginal zones of germinal centers in tonsil, lymph node, spleen. MNDA is a highly basic protein from 1q22, and is part of the family of nuclear proteins expressed in reaction to interferons. MNDA contains a Pyrin 'death domain' used in self-association and is suggested to induce or help prevent different programmed cell death pathways in hematopoietic cells.
MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated in Myelodysplastic Syndrome, a precursor for Leukemia. MNDA overexpression in Osteosarcoma induces apoptosis and protects patients from metastasis, and expression in Chronic Lymphocytic Leukemia indicates the degradation of anti-apoptotic mRNA, allowing cells suffering genotoxic stress to undergo apoptosis.
MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated in Myelodysplastic Syndrome, a precursor for Leukemia. MNDA overexpression in Osteosarcoma induces apoptosis and protects patients from metastasis, and expression in Chronic Lymphocytic Leukemia indicates the degradation of anti-apoptotic mRNA, allowing cells suffering genotoxic stress to undergo apoptosis.
Similar Products
Product Notes
The MNDA (Catalog #AAA370504) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MNDA (BSB-157) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "MNDA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
