Dilution Information
Rabbit anti-Human MTAP Monoclonal Antibody | anti-MTAP antibody
MTAP (RBT-MTAP)
Reactivity
Human
Synonyms
MTAP; Monoclonal Antibody; MTAP (RBT-MTAP); mtap; anti-mtap; m-tap; anti-m-tap; The S-methyl-5?-thioadenosine phosphorylase; methylthioadenosine phosphorylase; MeSAdo phosphorylase; MSAP; MTA phosphorylase; MTAPase; S methyl 5 thioadenosine phosphorylase; anti-MTAP antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-MTAP
Form/Format
Paraffin, Frozen
MTAP is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
MTAP is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human MTAP protein.
Control
Breast, Colon, Prostate, Testis, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(MTAP Antibody Immunohistochemistry on an FFPE Melanoma Tissue)
Immunohistochemistry (IHC)
(MTAP Antibody Immunohistochemistry on an FFPE Melanoma Tissue)
Related Product Information for anti-MTAP antibody
The S-methyl-5?-thioadenosine phosphorylase (MTAP) metabolizes methylthioadenosine (MTA), a byproduct of polyamine synthesis and regulator of protein methylation, to salvage adenine and methionine residues for reuse in many pathways affecting cell proliferation, signaling, and apoptosis. The MTAP gene, located at 9p12.3, is co-deleted with CDKN2A (encodes p16 tumor-suppressor) in several types of cancer and is abundant in all normal tissues but is deficient in various tumors.
IHC has been found to be an accurate and useful test method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high. Accumulated MTA can upregulate transcription factors, activate ERK pathways in Melanoma and MAPK in Liver Cancer causing invasive and metastasizing tumors, and disrupt function of secretory cells in tissues like the prostate. Disrupted DNA methylation affects epigenetic factors and can lead to dedifferentiated stem-like cancer cells in Glioblastoma, although these cells can suffer purine starvation without a functioning salvage pathway. Overexpression of MTAP is also associated with increased proliferation and epithelial-to-mesenchymal transition in Colorectal Carcinoma.
A study has found that a combination of MTAP antibody or BAP1 antibody loss detected by IHC can likely detect malignant pleural mesothelioma (MPM) with good sensitivity and 100% specificity, and serve as a useful ancillary IHC for discriminating MPM from reactive mesothelial hyperplasia (RMH).
IHC has been found to be an accurate and useful test method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high. Accumulated MTA can upregulate transcription factors, activate ERK pathways in Melanoma and MAPK in Liver Cancer causing invasive and metastasizing tumors, and disrupt function of secretory cells in tissues like the prostate. Disrupted DNA methylation affects epigenetic factors and can lead to dedifferentiated stem-like cancer cells in Glioblastoma, although these cells can suffer purine starvation without a functioning salvage pathway. Overexpression of MTAP is also associated with increased proliferation and epithelial-to-mesenchymal transition in Colorectal Carcinoma.
A study has found that a combination of MTAP antibody or BAP1 antibody loss detected by IHC can likely detect malignant pleural mesothelioma (MPM) with good sensitivity and 100% specificity, and serve as a useful ancillary IHC for discriminating MPM from reactive mesothelial hyperplasia (RMH).
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Product Notes
The MTAP (Catalog #AAA370505) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MTAP (RBT-MTAP) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "MTAP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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