Dilution Information
Rabbit anti-Human, Mouse CXCR4/CD184 Monoclonal Antibody | anti-CXCR4/CD184 antibody
CXCR4/CD184 (EP394)
Reactivity
Human, Mouse
Synonyms
CXCR4/CD184; Monoclonal Antibody; CXCR4/CD184 (EP394); CXCR4; anti-cxcr4; cd184; anti-cd184; fusin; anti-fusin; chemokine receptor 4; anti-chemokine; anti-CXCR4/CD184 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP394
Form/Format
Paraffin, Frozen
CXCR4/CD184 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CXCR4/CD184 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues of the human CXCR4 protein.
Control
Fallopian Tube, Adrenal Gland, Stomach, Kidney, Transitional Cell Caricnoma, T Cell Lymphoblastic Lymphoma, Tonsil, Testis
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CXCR4 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tissue)
Immunohistochemistry (IHC)
(CXCR4 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tissue)
Related Product Information for anti-CXCR4/CD184 antibody
Chemokine Receptor 4 (CXCR4, also CD184 or Fusin) is a homeostatic chemokine. Its major function is to regulate hematopoietic cell trafficking and secondary lymphoid tissue architecture. CXCR4 is widely expressed on Hematopoietic cells, including CD34+ HSC, T Lymphocytes, B Lymphocytes, Monocytes, Macrophages, Neutrophils, and Eosinophils, as well as organs including Brain, Heart, Colon, and Kidney, and Endothelial cells, Epithelial cells, and Smooth Muscle progenitors.
With roles in cell homing and tissue repair, CXCR4 is involved in cancer cell physiology, survival, and metastasis in >20 cancer types. CXCR4 induces and recruits stem cells and promotes angiogenesis in tumors, and responds to CXCL12 expression to promote metastasis in cancers of the Bone, Brain, Breast, Lung, Liver, Kidney, and other tissues. The SDF-1/CXCR4 axis plays a crucial role in engraftment, where CXCR4 antibody expression is correlated with inflammation and graft rejection. The most studied role for CXCL12 chemokine and its receptor CXCR4 in Breast Cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for Breast Cancer cell migration to other sites such as Lung, Bone, and Lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 antibody is being considered a prognostic marker in Breast Cancer.
With roles in cell homing and tissue repair, CXCR4 is involved in cancer cell physiology, survival, and metastasis in >20 cancer types. CXCR4 induces and recruits stem cells and promotes angiogenesis in tumors, and responds to CXCL12 expression to promote metastasis in cancers of the Bone, Brain, Breast, Lung, Liver, Kidney, and other tissues. The SDF-1/CXCR4 axis plays a crucial role in engraftment, where CXCR4 antibody expression is correlated with inflammation and graft rejection. The most studied role for CXCL12 chemokine and its receptor CXCR4 in Breast Cancer pathogenesis is the metastasis event, although several reports have demonstrated its involvement in other processes, such as angiogenesis and tumor growth. It has been found that CXCR4 is required for Breast Cancer cell migration to other sites such as Lung, Bone, and Lymph nodes, which express high levels of CXCL12 chemokine. Therefore, CXCR4 antibody is being considered a prognostic marker in Breast Cancer.
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Product Notes
The CXCR4/CD184 (Catalog #AAA370486) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CXCR4/CD184 (EP394) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CXCR4/CD184, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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