Dilution Information
Mouse anti-Human CXCL12/SDF-1 Monoclonal Antibody | anti-CXCL12/SDF-1 antibody
CXCL12/SDF-1 (BSB-165)
Reactivity
Human
Synonyms
CXCL12/SDF-1; Monoclonal Antibody; CXCL12/SDF-1 (BSB-165); cxcl12; anti-cxcl12; sdf-1; anti-sdf-1; sdf1; anti-sdf1; cytokine c-x-c motif chemokine 12; anti-cytokine; anti-CXCL12/SDF-1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-165
Form/Format
Paraffin, Frozen
CXCL12/SDF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CXCL12/SDF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human CXCL12/SDF?1 alpha protein.
Control
Testis, Breast, Colon, Fallopian Tube, Tonsil, Transitional Cell Carcinoma, T ell Lymphoblastic Lymphoma
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CXCL12 Antibody Immunohistochemistry on an FFPE Her-2 Negative Breast Carcinoma Tissue)
Immunohistochemistry (IHC)
(CXCL12 Antibody Immunohistochemistry on an FFPE Her-2 Negative Breast Carcinoma Tissue)
Related Product Information for anti-CXCL12/SDF-1 antibody
The cytokine C-X-C motif chemokine 12 (CXCL12) is synthesized by metastasis target tissues and has been shown to attract tumor cells that express the receptor, C-X-C chemokine receptor type 4 (CXCR4). CXCL12 is an inflammatory chemokine involved in Phospholipase C, MAPK, and PI3K-Akt-mTOR, and JAK/STAT pathways. CXCL12 interacts with its receptor CXCR4 to promote immunosuppression, chemotaxis, adhesion and migration, cell proliferation and survival. CXCL12 is involved in tumor protection and metastasis, where it induces angiogenesis and epithelial-to-mesenchymal transition and inhibits apoptosis and host immune response. CXCL12 is highly expressed in cancer-associated fibroblasts and tumor stroma, where it sequesters T cells and prevents them from infiltrating and attacking the tumor.
Expression of CXCL12 and CXCR4 in breast, pancreatic, esophageal, lung, prostate, and ovarian Cancers increases angiogenesis and is associated with poor prognosis, especially in the presence of HER2-neu which inhibits degradation of the CXCL12/CXCR4 signaling complex. Expression of CXCL12 in organs like lungs, lymph nodes, bone marrow, liver increases likelihood of metastasis to those sites. CXCL12 antibody expression and activity is controlled by hypoxia, ACKR3 (CXCR7) receptor, and post-translational modifications; CXCL12 hypermethylation has been reported in gastric, breast, colon, lung, and prostate cancer. A large study found high CXCL12 antibody expression associated with reduced overall survival in patients with oesophagogastric, pancreatic and lung cancer, whereas in breast cancer patients high CXCL12 expression conferred an overall survival advantage.
Expression of CXCL12 and CXCR4 in breast, pancreatic, esophageal, lung, prostate, and ovarian Cancers increases angiogenesis and is associated with poor prognosis, especially in the presence of HER2-neu which inhibits degradation of the CXCL12/CXCR4 signaling complex. Expression of CXCL12 in organs like lungs, lymph nodes, bone marrow, liver increases likelihood of metastasis to those sites. CXCL12 antibody expression and activity is controlled by hypoxia, ACKR3 (CXCR7) receptor, and post-translational modifications; CXCL12 hypermethylation has been reported in gastric, breast, colon, lung, and prostate cancer. A large study found high CXCL12 antibody expression associated with reduced overall survival in patients with oesophagogastric, pancreatic and lung cancer, whereas in breast cancer patients high CXCL12 expression conferred an overall survival advantage.
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Product Notes
The CXCL12/SDF-1 (Catalog #AAA370479) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CXCL12/SDF-1 (BSB-165) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CXCL12/SDF-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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