Dilution Information
Mouse SF-1/Steroidogenic Factor 1 Monoclonal Antibody | anti-SF-1 antibody
SF-1/Steroidogenic Factor 1 (BSB-149)
Reactivity
Human, Mouse, Rat
Synonyms
SF-1/Steroidogenic Factor 1; Monoclonal Antibody; SF-1/Steroidogenic Factor 1 (BSB-149); sf1; sf-1; sf 1; anti sf-1; anti-sf-1; anti-sf1; steroidogenic Factor 1; anti-steroidogenic; anti-SF-1 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
BSB-149
Form/Format
Paraffin, Frozen
Anti-SF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Anti-SF-1 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Pygopus 2 protein.
Control
Breast, Fallopian Tube, Colon, Bone Marrow, Testis, Transitional Cell Carcinoma, Lung Adenocarcinoma, Papillary Thyroid Carcinoma, Prostate Adenocarcinoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(SF-1 Antibody Immunohistochemistry on an FFPE Prostate Adenocarcinoma Tissue)
Immunohistochemistry (IHC)
(SF-1 Antibody Immunohistochemistry on an FFPE Prostate Adenocarcinoma Tissue)
Related Product Information for anti-SF-1 antibody
The Steroidogenic Factor 1 (SF-1) protein is a transcription factor involved in sex determination by controlling activity of genes related to the reproductive glands or gonads and adrenal glands. This protein is encoded by the NR5A1 gene. SF-1 expression is localized to adult steroidogenic tissues correlating with known expression profiles of steroid hydroxylases. Using in situ hybridization with SF-1 cRNA-specific probes detected gene transcripts in adrenocortical cells, Leydig cells, and ovarian theca and granulosa cells. SF-1 specific antibody studies confirmed the expression profile of SF-1 in rats and humans corresponding to sites of transcript detection.
SF-1 antibody has been found to be a highly valuable IHC marker to determine the adrenocortical origin of an adrenal mass with high sensitivity and specificity. In addition, SF-1 expression is of stage-independent prognostic value in patients with adrenocortical carcinoma. Other SF-1 pathologies include adrenal failure (mutations in the SF-1 DNA-binding interface), adrenal or ovarian insufficiency and gonadal dysgenesis (heterozygous mutations), endometriosis (promoter hypomethylation), and male infertility (mutations in the hinge region of the protein). For the differential identification with endometrioid tumors and carcinoid of the ovary, SF-1 antibody is a sensitive and specific IHC marker for Sertoli cell tumor and that SF-1 is testally comparable with other good sex cord-stromal markers.
SF-1 antibody has been found to be a highly valuable IHC marker to determine the adrenocortical origin of an adrenal mass with high sensitivity and specificity. In addition, SF-1 expression is of stage-independent prognostic value in patients with adrenocortical carcinoma. Other SF-1 pathologies include adrenal failure (mutations in the SF-1 DNA-binding interface), adrenal or ovarian insufficiency and gonadal dysgenesis (heterozygous mutations), endometriosis (promoter hypomethylation), and male infertility (mutations in the hinge region of the protein). For the differential identification with endometrioid tumors and carcinoid of the ovary, SF-1 antibody is a sensitive and specific IHC marker for Sertoli cell tumor and that SF-1 is testally comparable with other good sex cord-stromal markers.
Similar Products
Product Notes
The SF-1 (Catalog #AAA370512) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SF-1/Steroidogenic Factor 1 (BSB-149) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "SF-1/Steroidogenic Factor 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
