Dilution Information
Rabbit anti-Human HSP70 Monoclonal Antibody | anti-HSP70 antibody
HSP70 (RM432)
Reactivity
Human
Synonyms
HSP70; Monoclonal Antibody; HSP70 (RM432); hsp-70; anti-hsp70; anti-hsp-70; heat shock protein; anti-HSP70 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM432
Form/Format
Paraffin, Frozen
HSP70 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
HSP70 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human HSP70 protein.
Control
Breast, Fallopian Tube, Skin, Prostate, Testis, Transitional Cell Carcinoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(HSP70 Antibody Immunohistochemistry on an FFPE Colon Adenocarcinoma Tissue)
Immunohistochemistry (IHC)
(HSP70 Antibody Immunohistochemistry on an FFPE Colon Adenocarcinoma Tissue)
Related Product Information for anti-HSP70 antibody
70 kDa heat shock proteins (HSP70) are found ubiquitously in virtually all living organisms, facilitating protein folding and protecting cells from heat stress and toxic chemicals. HSP70 proteins have 3 functional domains: N-terminal ATPase domain, substrate binding domain, and a C-terminal domain that serves as a "lid" for the substrate binding domain. HSP70 binds tightly to partially synthesized peptides and prevents them from aggregating and rendering nonfunctional. HSP70 also inhibits apoptosis by blocking the recruitment of procaspase-9 to the Apaf-1/dATP/cytochrome c apoptosome complex.
HSP70 antibody is shown to be overexpressed in malignant Melanoma and underexpressed in Renal Cell Carcinoma. A variety of tumor cells can express HSP70 with seemingly contradictory functions. Intracellular HSP70 has a cytoprotective function via suppression of apoptosis and lysosomal cell death (LCD) and extracellular HSP70 can promote tumorigenesis and angiogenesis. Other evidence showed intracellular HSP70 can promote apoptosis and membrane-associated/extracellular HSP70 can elicit antitumor innate and adaptive immune responses.
One study evaluated the expression of HSP70 antibody, Estrogen Receptor (ER) and Ki-67 and assessed the relationship between them in Cervical Squamous Cell Neoplasia. It found that HSP70 may play an important role in tumor cell proliferation and is more related with invasive Squamous Cell Carcinoma than Cervical Intraepithelial Neoplasia, but ER may be not related with tumor cell proliferation and differentiation. Therefore, HSP70 may be a useful prognostic factor in Cervical Dysplasia and Cancer.
HSP70 antibody is shown to be overexpressed in malignant Melanoma and underexpressed in Renal Cell Carcinoma. A variety of tumor cells can express HSP70 with seemingly contradictory functions. Intracellular HSP70 has a cytoprotective function via suppression of apoptosis and lysosomal cell death (LCD) and extracellular HSP70 can promote tumorigenesis and angiogenesis. Other evidence showed intracellular HSP70 can promote apoptosis and membrane-associated/extracellular HSP70 can elicit antitumor innate and adaptive immune responses.
One study evaluated the expression of HSP70 antibody, Estrogen Receptor (ER) and Ki-67 and assessed the relationship between them in Cervical Squamous Cell Neoplasia. It found that HSP70 may play an important role in tumor cell proliferation and is more related with invasive Squamous Cell Carcinoma than Cervical Intraepithelial Neoplasia, but ER may be not related with tumor cell proliferation and differentiation. Therefore, HSP70 may be a useful prognostic factor in Cervical Dysplasia and Cancer.
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Product Notes
The HSP70 (Catalog #AAA370496) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HSP70 (RM432) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "HSP70, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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