Dilution Information
Rabbit anti-Human ATM Monoclonal Antibody | anti-ATM antibody
ATM (EP327)
Reactivity
Human
Synonyms
ATM; Monoclonal Antibody; ATM (EP327); anti-atm; anti atm; Ataxia telangiectasia mutated protein; anti-ATM antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP327
Form/Format
Paraffin, Frozen
Anti-ATM is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Anti-ATM is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues of the human ATM protein.
Control
Fallopian Tube, Brain, Colon, Breast, Testis, Tonsil, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(ATM Antibody Immunohistochemistry on a FFPE CLL/SLL Lymphoma Tissue)
Immunohistochemistry (IHC)
(ATM Antibody Immunohistochemistry on a FFPE CLL/SLL Lymphoma Tissue)
Related Product Information for anti-ATM antibody
Ataxia telangiectasia mutated (ATM) protein is a serine/threonine kinase that belongs to the family of phosphatidylinositol-3 kinase (PI3K)- related protein kinases. ATM is a key checkpoint protein of the DNA damage response pathway. When DNA double-strand breaks occur, ATM activates different cascades, resulting in activation of cell cycle checkpoints, cell cycle arrests, and apoptosis.
Mutations in the ATM gene lead to an increased risk of several cancer types, which include Leukemias, Lymphomas, Colorectal Cancer, Pancreatic Cancer and Adenocarcinoma of the Stomach. Studies show that Gastric Cancer tissues were found to be negative fomr the ATM antibody by IHC staining, indicating that ATM can be used as a biomarker. It has also been found that low expression of the ATM antibody contributes to more aggressive progression and poor clinical outcome of Breast Cancer. Results of another study indicate loss of ATM antibody expression is associated with development of Lung Cancer.
Mutations in the ATM gene lead to an increased risk of several cancer types, which include Leukemias, Lymphomas, Colorectal Cancer, Pancreatic Cancer and Adenocarcinoma of the Stomach. Studies show that Gastric Cancer tissues were found to be negative fomr the ATM antibody by IHC staining, indicating that ATM can be used as a biomarker. It has also been found that low expression of the ATM antibody contributes to more aggressive progression and poor clinical outcome of Breast Cancer. Results of another study indicate loss of ATM antibody expression is associated with development of Lung Cancer.
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Product Notes
The ATM (Catalog #AAA370476) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The ATM (EP327) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "ATM, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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