Dilution Information
Rabbit anti-Human Aurora B Monoclonal Antibody
Aurora B (RM278)
Reactivity
Human
Synonyms
Aurora B; Monoclonal Antibody; Aurora B (RM278); aurora b; anti-aurora b; aurora b kinase; anti-Aurora B antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM278
Form/Format
Paraffin, Frozen
Anti-Aurora B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Anti-Aurora B is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the N-terminus of human Aurora kinase B.
Control
Tonsil, Colon, Stomach, Skin, Transitional Cell Carcinoma, T Cell Lymphoblastic Lymphoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(Aurora B Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Immunohistochemistry (IHC)
(Aurora B Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Related Product Information for anti-Aurora B antibody
Aurora B kinase, a 39.3 kDa sized serine-threonine kinase, is a member of the Aurora family of mitotic kinases. The enzymatic activity of Aurora B kinase prevents stable kinetochore-microtubule attachments in early mitosis and promotes stabilization of the attachments in later mitosis due to low activity. The gene for Aurora B kinase (AURKB) is located on chromosome 17p13.1.
Abnormal expression of Aurora B antibody has been found in many cancer types, such as Non-Small Cell Lung Carcinoma, Mesothelioma, Glioblastoma, Oral Cancer and Hepatocellular Carcinoma. In Prostate and Colorectal Cancer, Aurora B expression directly correlates with the progression of cancer. In a study investigating the expression of Aurora B kinase in Thyroid Carcinoma, abundant expression of Aurora B kinase was detected in Anaplastic Carcinomas via IHC. A higher expression of Aurora B kinase in Anaplastic Thyroid Cancer than in differentiated Thyroid Cancer therefore suggests its use as a prognostic marker. In another immunohistochemical analysis, Aurora B antibody showed nuclear overexpression in high Gleason-grade Prostate Cancer, compared to low and intermediate grade cases. Additionally, there are numerous studies that indicate the use of Aurora B kinase as a prognostic marker in Ovarian Cancer. A study found that Aurora-B expression was correlated with the proliferation index (P < 0.001) and p53 expression (P = 0.014) in Breast cancer tissues and its expression was associated with lymph node metastasis (P = 0.002) and histological grade (P = 0.001). In conclusion, elevated Aurora-B expression in Breast Cancer patients contributes to chemoresistance and predicts poor prognosis.
Abnormal expression of Aurora B antibody has been found in many cancer types, such as Non-Small Cell Lung Carcinoma, Mesothelioma, Glioblastoma, Oral Cancer and Hepatocellular Carcinoma. In Prostate and Colorectal Cancer, Aurora B expression directly correlates with the progression of cancer. In a study investigating the expression of Aurora B kinase in Thyroid Carcinoma, abundant expression of Aurora B kinase was detected in Anaplastic Carcinomas via IHC. A higher expression of Aurora B kinase in Anaplastic Thyroid Cancer than in differentiated Thyroid Cancer therefore suggests its use as a prognostic marker. In another immunohistochemical analysis, Aurora B antibody showed nuclear overexpression in high Gleason-grade Prostate Cancer, compared to low and intermediate grade cases. Additionally, there are numerous studies that indicate the use of Aurora B kinase as a prognostic marker in Ovarian Cancer. A study found that Aurora-B expression was correlated with the proliferation index (P < 0.001) and p53 expression (P = 0.014) in Breast cancer tissues and its expression was associated with lymph node metastasis (P = 0.002) and histological grade (P = 0.001). In conclusion, elevated Aurora-B expression in Breast Cancer patients contributes to chemoresistance and predicts poor prognosis.
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Product Notes
The Aurora B (Catalog #AAA370478) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Aurora B (RM278) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Aurora B, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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