Dilution Information
Mouse anti-Human IFN-Alpha Monoclonal Antibody | anti-IFN-Alpha antibody
IFN-Alpha (BSB-158)
Reactivity
Human
Synonyms
IFN-Alpha; Monoclonal Antibody; IFN-Alpha (BSB-158); ifn-a; anti-ifn-a; ifna; anti-ifna; ifn a; anti-ifn a; IFN-alpha; anti-IFN-alpha; inf alpha; ifn-alpha; anti-ifn-alpha; anti-IFN-Alpha antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
BSB-158
Form/Format
Paraffin, Frozen
IFN-a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
IFN-a is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human IFN-alpha1 protein.
Control
Placenta, Fallopian Tube, Stomach, Prostate, Testis, Transitional Cell Carcinoma, Papillary Thyroid Carcinoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(IFN-a Antibody Immunohistochemistry on an FFPE Papillary Thyroid Carcinoma Tissue)
Immunohistochemistry (IHC)
(IFN-a Antibody Immunohistochemistry on an FFPE Papillary Thyroid Carcinoma Tissue)
Related Product Information for anti-IFN-Alpha antibody
Type I interferons are a large subgroup of interferon proteins that help regulate the immune system by binding to IFN-? receptors. IFN-? (IFN-a) is produced mainly by plasmacytoid dendritic cells and involved in innate immunity against viral infections. Binding of IFN-? to its receptor leads to downstream signalling and expression of numerous different IFN-stimulated genes. These genes encode antiviral proteins that directly inhibit viral replication as well as modulate immune function.
Studies have shown IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-gamma secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2. IFN-a can also interact with the u-opioid receptor to act as an analgesic. Additionally, recent studies have shown that Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor cells which can enhance antitumor CD8 T cell effector response in the tumor microenvironment.
Studies have shown IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-gamma secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever. It does this by binding to opioid receptors and eliciting the release of prostaglandin-E2. IFN-a can also interact with the u-opioid receptor to act as an analgesic. Additionally, recent studies have shown that Type 1 IFNs stimulate secretion of IP-10 (CXCL10) which is a critical chemokine to recruit effector T cells to the tumor microenvironment and IP-10 knockout mice exhibit a phenotype with compromised effector T cell generation and trafficking. Type 1 IFNs also induce MHC class 1 upregulation on tumor cells which can enhance antitumor CD8 T cell effector response in the tumor microenvironment.
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Product Notes
The IFN-Alpha (Catalog #AAA370499) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The IFN-Alpha (BSB-158) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "IFN-Alpha, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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