Dilution Information
Mouse anti-Human SOX-11 Monoclonal Antibody | anti-SOX-11 antibody
SOX-11 (BSB-167)
Reactivity
Human
Synonyms
SOX-11; Monoclonal Antibody; SOX-11 (BSB-167); sox-11;sox11; anti-sox-11; anti-sox11; transcription factor sox-11; anti-SOX-11 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-167
Form/Format
Paraffin, Frozen
SOX-11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
SOX-11 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the N-terminus of the human SOX-11 protein.
Control
Mantle Cell Lymphoma, Lung Neuroendocrine Carcinoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(SOX-11 Antibody Immunohistochemistry on an FFPE Mantle Cell Lymphoma Tissue)
Immunohistochemistry (IHC)
(SOX-11 Antibody Immunohistochemistry on an FFPE Mantle Cell Lymphoma Tissue)
Related Product Information for anti-SOX-11 antibody
Transcription factor SOX-11 is a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and plays a role in tumorigenesis and adult neurogenesis. SOX-11 antibody is normally expressed in the developing human central nervous system, medulloblastoma, and glioma.
SOX-11 antibody nuclear expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas, with a stronger and more homogeneous Immunostain than cyclin D1. Absence of SOX-11 expression in mantle cell lymphoma (MCL) may be a characteristic of indolent MCL. Sensitivity and specificity for combined SOX-11 and cyclin D1 immunohistostaining in the identification of cutaneous mantle cell lymphoma are both 100%. SOX-11 has also been detected in rare cases of Burkitt lymphoma, lymphoblastic lymphoma and T cell prolymphocytic leukemia and overexpression can be seen in malignant gliomas.
SOX-11 antibody nuclear expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas, with a stronger and more homogeneous Immunostain than cyclin D1. Absence of SOX-11 expression in mantle cell lymphoma (MCL) may be a characteristic of indolent MCL. Sensitivity and specificity for combined SOX-11 and cyclin D1 immunohistostaining in the identification of cutaneous mantle cell lymphoma are both 100%. SOX-11 has also been detected in rare cases of Burkitt lymphoma, lymphoblastic lymphoma and T cell prolymphocytic leukemia and overexpression can be seen in malignant gliomas.
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Product Notes
The SOX-11 (Catalog #AAA370548) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SOX-11 (BSB-167) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "SOX-11, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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