Dilution Information
Mouse anti-Human CD137/TNFRSF9 Monoclonal Antibody | anti-CD137/TNFRSF9 antibody
CD137/TNFRSF9 (BSB-159)
Reactivity
Human
Synonyms
CD137/TNFRSF9; Monoclonal Antibody; CD137/TNFRSF9 (BSB-159); cd137; anti-cd137; tnfrsf9; anti-tnfrsf9; tumor necrosis factor receptor superfamily member 9; anti-CD137/TNFRSF9 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgM
Clone Number
BSB-159
Form/Format
Paraffin, Frozen
CD137/TNFRSF9 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CD137/TNFRSF9 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the N-terminus of the human CD137 protein.
Control
Colon, Stomach, Tonsil, Testis, Transitional Cell Carcinoma, DBC, Hepatocellular Carcinoma, Diffuse Type Gastric Carcinoma
Localization
Nuclear, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CD137 Antibody Immunohistochemistry on an FFPE Transitional Cell Carcinoma Tissue)
Immunohistochemistry (IHC)
(CD137 Antibody Immunohistochemistry on an FFPE Transitional Cell Carcinoma Tissue)
Related Product Information for anti-CD137/TNFRSF9 antibody
CD137, or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as 4-1BB, is encoded by the TNFRSF9 gene on chromosome 1p36.23. CD137/TNFRSF9 is expressed on the surface of certain immune cells, such as Follicular Dendritic Cells, Monocytes, Mast Cells and Granulocytes. CD137/TNFRSF9 is barely detected on resting T cells or T-cell lines, and expression of CD137 is therefore activation dependent. It is found on activated CD4+, CD8+ or Natural Killer Cells. Activation of CD137 by its ligand, CD137L, upregulates survival genes, enhances cell division, induces cytokine production, and prevents activation-induced cell death in T cells.
One study demonstrated CD137 antibody positive IHC staining in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a test biomarker for CHL. CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells. Another study investigated CD137/TNFRSF9 via IHC in malignant tumor cells and found that there was an enhanced expression of CD137/TNFRSF9 in blood vessel cells of malignant tumors compared to blood vessel cells in benign tumors or inflammatory tissues. Further studies indicate the value of CD137 antibody as a prognostic marker in Diffuse Large B-cell Lymphomas, tumor cell differentiation in Gastric Cancer as well as the correlation between CD137/TNFRSF9 expression and bone metastasis of Breast Cancer. CD137/TNFRSF9 is considerably up-regulated in human Gliomas when compared with normal brain tissue. In addition, data provides evidence for an immune cell-independent de novo expression pattern of CD137/TNFRSF9 in mainly non-neoplastic reactive astrocytes and excludes classic immunological cell types, namely lymphocytes and microglia as the source of CD37/TNFRSF9. Moreover, TNFRSF9 is predominantly expressed in a perivascular and peritumoural distribution with significantly higher expression in IDH-1 mutant gliomas.
One study demonstrated CD137 antibody positive IHC staining in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a test biomarker for CHL. CD137/TNFRSF9 was also found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells. Another study investigated CD137/TNFRSF9 via IHC in malignant tumor cells and found that there was an enhanced expression of CD137/TNFRSF9 in blood vessel cells of malignant tumors compared to blood vessel cells in benign tumors or inflammatory tissues. Further studies indicate the value of CD137 antibody as a prognostic marker in Diffuse Large B-cell Lymphomas, tumor cell differentiation in Gastric Cancer as well as the correlation between CD137/TNFRSF9 expression and bone metastasis of Breast Cancer. CD137/TNFRSF9 is considerably up-regulated in human Gliomas when compared with normal brain tissue. In addition, data provides evidence for an immune cell-independent de novo expression pattern of CD137/TNFRSF9 in mainly non-neoplastic reactive astrocytes and excludes classic immunological cell types, namely lymphocytes and microglia as the source of CD37/TNFRSF9. Moreover, TNFRSF9 is predominantly expressed in a perivascular and peritumoural distribution with significantly higher expression in IDH-1 mutant gliomas.
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Product Notes
The CD137/TNFRSF9 (Catalog #AAA370483) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD137/TNFRSF9 (BSB-159) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD137/TNFRSF9, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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