Related Product Information for anti-KCNAB1 antibody
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes-shaker, shaw, shab, and shal-have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.
Product Categories/Family for anti-KCNAB1 antibody
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Decher, N., et al. EMBO J. 27(23):3164-3174(2008). Cavalleri, G.L., et al. Lancet Neurol 6(11):970-980(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007). Lunetta, K.L., et al. BMC Med. Genet. 8 SUPPL 1, S13 (2007).
NCBI Description
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits. [provided by RefSeq, Jul 2008]
Uniprot Description
Kv-beta1: Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. All three isoforms alter the functional properties of Kv1.4 and Kv1.5. Isoform KvB1.2 has no effect on Kv1.1, Kv1.2 or Kv2.1. Belongs to the shaker potassium channel beta subunit family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, potassium
Chromosomal Location of Human Ortholog: 3q26.1
Cellular Component: extrinsic to internal side of plasma membrane; plasma membrane; cytosol
Molecular Function: voltage-gated potassium channel activity; potassium channel regulator activity; aldo-keto reductase activity
Biological Process: synaptic transmission; learning and/or memory; potassium ion transport
Product Notes
The KCNAB1 kcnab1 (Catalog #
AAA6312272) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The KCNAB1, NT (KCNAB1, KCNA1B, Voltage-gated potassium channel subunit beta-1, K(+) channel subunit beta-1, Kv-beta-1) (FITC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's KCNAB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the KCNAB1 kcnab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"KCNAB1, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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