Dilution Information
Rabbit anti-Human CD73/NT5E Monoclonal Antibody | anti-CD73/NT5E antibody
CD73/NT5E (RM431)
Reactivity
Human
Synonyms
CD73/NT5E; Monoclonal Antibody; CD73/NT5E (RM431); cd73; anti-cd73; nt5e; anti-nt5e; Ecto-5'-nucleotidase; anti-Ecto-5'-nucleotidase; anti-CD73/NT5E antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM431
Form/Format
Paraffin, Frozen
CD73/NT5E is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CD73/NT5E is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human CD73 protein.
Control
Placenta, Adrenal Gland, Liver, Testis, Transitional Cell Carcinoma, Ovarian Serous Carcinoma
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CD73 Antibody Immunohistochemistry on an FFPE Papillary Thyroid Carcinoma Tissue)
Immunohistochemistry (IHC)
(CD73 Antibody Immunohistochemistry on an FFPE Papillary Thyroid Carcinoma Tissue)
Related Product Information for anti-CD73/NT5E antibody
Ecto-5'-nucleotidase (NT5E), or also known as CD73, encoded by the NT5E gene on the human chromosome 6q14.3, is a dimer of two identical 70 kDa subunits. The mature form of CD73 has a molecular weight of 61 kDa. As a plasma membrane protein and expressed in various cell types, CD73 hydrolyzes extracellular adenosine monophosphate (AMP) into adenosine and inorganic phosphate. It performs homeostatic functions and plays an important role in immunity and inflammation. In cells of the immune system, CD73, in combination with CD39, serves as an immunological switch that turns the cell activity from pro-inflammatory toward anti-inflammatory, which is mediated by adenosine.
In a study that analyzed several publications conducting IHC analysis, CD73 antibody overexpression was found to be associated with several types of human cancers including Bladder, Brain, Invasive Lobular Breast, Esophageal, Gastric, Pancreatic, Rectal mucinous, Renal Cell, Lung Large Cell, oral cavity Squamous Cell, Melanoma, and Lung Adenocarcinoma Cancers. Studies also found that lymph node metastases correlated with high CD73 expression. One study investigated CD73 in Non-Small Cell Lung Cancer (NSCLC) tissues by IHC and found that CD73 expression is frequently higher in NSCLC tissue, compared to normal tissue, which indicates the prognostic value of CD73 in the tumorigenesis of NSCLC. Another study revealed the prognostic potential of CD73 antibody as a biomarker in Breast Cancer, since CD73 is associated with cancer cell invasion, migration and lymph node metastasis. Other studies showed a positive correlation between CD73 expression with Colorectal Cancer malignancy, and metastatic Melanomas.
In a study that analyzed several publications conducting IHC analysis, CD73 antibody overexpression was found to be associated with several types of human cancers including Bladder, Brain, Invasive Lobular Breast, Esophageal, Gastric, Pancreatic, Rectal mucinous, Renal Cell, Lung Large Cell, oral cavity Squamous Cell, Melanoma, and Lung Adenocarcinoma Cancers. Studies also found that lymph node metastases correlated with high CD73 expression. One study investigated CD73 in Non-Small Cell Lung Cancer (NSCLC) tissues by IHC and found that CD73 expression is frequently higher in NSCLC tissue, compared to normal tissue, which indicates the prognostic value of CD73 in the tumorigenesis of NSCLC. Another study revealed the prognostic potential of CD73 antibody as a biomarker in Breast Cancer, since CD73 is associated with cancer cell invasion, migration and lymph node metastasis. Other studies showed a positive correlation between CD73 expression with Colorectal Cancer malignancy, and metastatic Melanomas.
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Product Notes
The CD73/NT5E (Catalog #AAA370482) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CD73/NT5E (RM431) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD73/NT5E, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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