Dilution Information
Mouse PAX-7 Monoclonal Antibody | anti-PAX-7 antibody
PAX-7 (BSB-145)
Reactivity
Human, Mouse, Rat
Synonyms
PAX-7; Monoclonal Antibody; PAX-7 (BSB-145); pax-7; pax7; pax 7; anti-pax-7; anti-pax7; anti-pax 7; paired box gene 7; anti-PAX-7 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
BSB-145
Form/Format
Paraffin, Frozen
PAX-7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
PAX-7 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant PAX-7 of human origin.
Control
Breast, Lung, SKin, Testis, Cervix, Papillary Thyroid Carcinoma, Ewing Sarcoma
Localization
Nuclear, Cytoplasmic
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(PAX-7 Antibody Immunohistochemistry on an FFPE Renal Cell Carcinoma Tissue)
Immunohistochemistry (IHC)
(PAX-7 Antibody Immunohistochemistry on an FFPE Renal Cell Carcinoma Tissue)
Related Product Information for anti-PAX-7 antibody
PAX-7 or Paired Box Gene 7 is a transcription factor coded by a gene on locus 1p36, which can fuse with Forkhead Domain Region (FKHR). PAX-7 protein is involved in developmental pathways in neural tube and mesencephalon formation, muscle cell development, and oxidative stress sensitivity. PAX-7 regulates neural cell adhesion molecules and is expressed in proliferating myoblasts, but it is down-regulated after playing its role in cell differentiation toward muscle-derived specification.
PAX-7 is restricted to muscle satellite and myogenic precursor cells in adults, although it is upregulated in embryonal (ERMS) and alveolar rhabdomyosarcoma (ARMS) and could suggest a de-differentiated cell type when overexpressed in these tumors. Recent studies suggested that PAX-7 antibody is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. PAX-7 antibody was found expressed in 90% of Ewing sarcomas (90%), mainly in a diffuse and strong manner. Although NKX2-2 showed similar sensitivity, PAX-7 showed more extensive and strong reactivity. ARMS differs from ERMS by virtue of its occurrence in older patients, distinctive pseudoalveolar pattern, usual absence of strap cells, and strong myogenin rather than MyoD1 expression. Identification of a PAX3 or PAX-7/FKHR fusion gene may be necessary for the confident distinction of ARMS from the most primitive forms of ERMS.
PAX-7 is restricted to muscle satellite and myogenic precursor cells in adults, although it is upregulated in embryonal (ERMS) and alveolar rhabdomyosarcoma (ARMS) and could suggest a de-differentiated cell type when overexpressed in these tumors. Recent studies suggested that PAX-7 antibody is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. PAX-7 antibody was found expressed in 90% of Ewing sarcomas (90%), mainly in a diffuse and strong manner. Although NKX2-2 showed similar sensitivity, PAX-7 showed more extensive and strong reactivity. ARMS differs from ERMS by virtue of its occurrence in older patients, distinctive pseudoalveolar pattern, usual absence of strap cells, and strong myogenin rather than MyoD1 expression. Identification of a PAX3 or PAX-7/FKHR fusion gene may be necessary for the confident distinction of ARMS from the most primitive forms of ERMS.
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Product Notes
The PAX-7 (Catalog #AAA370509) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PAX-7 (BSB-145) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "PAX-7, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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