Dilution Information
Rabbit anti-Human Nanog Monoclonal Antibody
Nanog (EP225)
Reactivity
Human
Synonyms
Nanog; Monoclonal Antibody; Nanog (EP225); NANOG; Nanog homeobox; anti-Nanog; anti Nanog; anti-Nanog homeobox; anti Nanog homeobox; Nanog gene product; anti-Nanog gene product; anti Nanog gene product; hNanog; homeobox protein NANOG; Homeobox transcription factor Nanog; homeobox transcription factor Nanog delta 48; anti-Nanog antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP225
Form/Format
Paraffin, Frozen
Nanog is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Nanog is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
A synthetic peptide corresponding to residues of human Nanog protein.
Control
Testis, Cervix, Seminoma, Embryonal Carcinoma, TCC
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(Nanog Antibody Immunohistochemistry on an FFPE Seminoma Tissue)
Immunohistochemistry (IHC)
(Nanog Antibody Immunohistochemistry on an FFPE Seminoma Tissue)
Related Product Information for anti-Nanog antibody
Homeobox protein Nanog is a transcriptional factor that helps embryonic stem cells (ESCs) maintain pluripotency by suppressing cell determination factors. In humans, this protein is encoded by the NANOG gene. Nanog is thought to function in concert with other factors such as Oct-4 and SOX2 to establish ESC identity. Nanog is highly expressed in cancer stem cells and thus may function as an oncogene to promote carcinogenesis. High expression of Nanog correlates with poor survival in cancer patients.
Nanog antibody is highly and specifically expressed in carcinoma in situ (CIS), embryonal carcinomas, and seminomas, but not in teratomas and yolk sac tumors. Additionally, it has been reported that Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Positive Nanog expression is significantly associated with high-grade ovarian serous carcinoma and is absent in benign, borderline, and low-grade serous lesions. A study suggests the expression of Nanog exhibiting cellular shuttling behavior and increasing stromal distribution during the progression of cervical cancer. Recently it was suggested that Nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased overall survival (OS) and disease-free survival (DFS) for lung cancer.
Nanog antibody is highly and specifically expressed in carcinoma in situ (CIS), embryonal carcinomas, and seminomas, but not in teratomas and yolk sac tumors. Additionally, it has been reported that Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. Positive Nanog expression is significantly associated with high-grade ovarian serous carcinoma and is absent in benign, borderline, and low-grade serous lesions. A study suggests the expression of Nanog exhibiting cellular shuttling behavior and increasing stromal distribution during the progression of cervical cancer. Recently it was suggested that Nanog overexpression, a hazard factor of differentiation, lymph node metastasis, and tumor size, may predicate decreased overall survival (OS) and disease-free survival (DFS) for lung cancer.
Similar Products
Product Notes
The Nanog (Catalog #AAA370441) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Nanog (EP225) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Nanog, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
