Dilution Information
Mouse CD142/TF/Coagulation Factor III Monoclonal Antibody | anti-CD142/TF antibody
CD142/TF/Coagulation Factor III (BSB-143)
Reactivity
Human, Mouse, Rat
Synonyms
CD142/TF/Coagulation Factor III; Monoclonal Antibody; CD142/TF/Coagulation Factor III (BSB-143); cd143; anti-cd142; tf; anti-tf; coagulation factor iii; coagulation factor 3; anti-coagulation factor; tissue factor; anti-tissue factor; thromboplastin; anti-thromboplastin; anti-CD142/TF antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
BSB-143
Form/Format
Paraffin, Frozen
CD142 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
CD142 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the internal region of the human CD142 protein.
Control
Placenta, Cervix, Colon, Pancreas, Brain, Kidney, Testis, Pancreatic Carcinoma, Colon Adenocarcinoma
Localization
Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(CD142 Antibody Immunohistochemistry on an FFPE SARS-CoV-2 Infected Lung Tissue)
Immunohistochemistry (IHC)
(CD142 Antibody Immunohistochemistry on an FFPE SARS-CoV-2 Infected Lung Tissue)
Related Product Information for anti-CD142/TF antibody
CD142, also known as Tissue Factor (TF) or Coagulation Factor III or Thromboplastin, is encoded by the F3 gene located on chromosome 1p21.3. CD142 /TF is a 46 kDa sized integral membrane glycoprotein. Upon complex formation with coagulation factor VII, extrinsic blood coagulation is activated by a catalytic cascade that involves specific proteolysis.
CD142 antibody is not only associated with the progression, but also with the overall survival rate of many cancers, including breast, gastrointestinal, liver, pancreatic, and prostate cancer. A study that investigated CD142 antibody expression in non-small-cell lung cancer (NSCLC) found that immunohistochemical staining was increased in NSCLC patients with metastasis, compared to patients without metastasis, indicating the critical role of CD142 in the progression of NSCLC. A study found increased CD142 levels in breast cancer tissue as well as a correlation between poor survival and high levels of CD142 expression in breast cancer patients. Overexpression of TF in fibrosarcoma, in gastric cancer cells and in melanoma cells enhances tumour growth by diminishing the transcription of antiangiogenic thrombospondins and/or by increasing the transcription of pro-angiogenic VEGF.
The SARS-CoV-2 virus triggers the synthesis and release of pro-inflammatory cytokines, including IL-6 and TNF-alpha and also promotes downregulation of ACE-2, which promotes a concomitant increase in levels of angiotensin II (AT-II). Both TNF-alpha and AT-II have been implicated in promoting overexpression of tissue factor (TF) in platelets and macrophages. Additionally, the generation of antiphospholipid antibodies associated with COVID-19 may also promote an increase in TF. TF may be a critical mediator associated with the development of thrombotic phenomena in COVID-19.
CD142 antibody is not only associated with the progression, but also with the overall survival rate of many cancers, including breast, gastrointestinal, liver, pancreatic, and prostate cancer. A study that investigated CD142 antibody expression in non-small-cell lung cancer (NSCLC) found that immunohistochemical staining was increased in NSCLC patients with metastasis, compared to patients without metastasis, indicating the critical role of CD142 in the progression of NSCLC. A study found increased CD142 levels in breast cancer tissue as well as a correlation between poor survival and high levels of CD142 expression in breast cancer patients. Overexpression of TF in fibrosarcoma, in gastric cancer cells and in melanoma cells enhances tumour growth by diminishing the transcription of antiangiogenic thrombospondins and/or by increasing the transcription of pro-angiogenic VEGF.
The SARS-CoV-2 virus triggers the synthesis and release of pro-inflammatory cytokines, including IL-6 and TNF-alpha and also promotes downregulation of ACE-2, which promotes a concomitant increase in levels of angiotensin II (AT-II). Both TNF-alpha and AT-II have been implicated in promoting overexpression of tissue factor (TF) in platelets and macrophages. Additionally, the generation of antiphospholipid antibodies associated with COVID-19 may also promote an increase in TF. TF may be a critical mediator associated with the development of thrombotic phenomena in COVID-19.
Similar Products
Product Notes
The CD142/TF (Catalog #AAA370484) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD142/TF/Coagulation Factor III (BSB-143) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "CD142/TF/Coagulation Factor III, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
