Dilution Information
Rabbit anti-Human, Mouse LIN28 Monoclonal Antibody | anti-LIN28 antibody
LIN28 (EP150)
Reactivity
Human, Mouse
Synonyms
LIN28; Monoclonal Antibody; LIN28 (EP150); LIN 28; LIN28A; CSDD1; FLJ12457; lin 28 homolog A C elegans; lin 28A; Protein lin 28 homolog A; RNA binding protein LIN 28; ZCCHC1; zinc finger CCHC domain containing protein 1; zinc finger CCHC domain containing 1; anti-lin28; anti-lin-28; lin-28; anti-lin 28; anti lin28; anti lin-28; anti lin 28; anti-LIN28 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP150
Form/Format
Paraffin, Frozen
LIN28 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
LIN28 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues of the C-terminus of human LIN28Aprotein.
Control
Testis, Seminoma, Dysgerminoma, Yolk Sac Tumor, Embryonal Carcinoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(LIN28 Antibody Immunohistochemistry on an FFPE Seminoma Tissue)
Immunohistochemistry (IHC)
(LIN28 Antibody Immunohistochemistry on an FFPE Seminoma Tissue)
Related Product Information for anti-LIN28 antibody
LIN28 homolog A is a protein that in humans is encoded by the LIN28 gene. LIN28 is thought to regulate the self-renewal of stem cells, is highly expressed in human embryonic stem cells and can enhance the efficiency of the formation of induced pluripotent stem (iPS) cells from human fibroblasts.
LIN28 antibody has been found to be a highly sensitive marker for testicular intratubular germ cell neoplasias, classic seminomas, embryonal carcinomas, and yolk sac tumors (YST) with relatively high specificity. LIN28 can be used as a test marker for these tumors and has demonstrated a similar level of test utility as SALL4. The major advantage of LIN28 over OCT4 is in identifying yolk sac tumors (yolk sac tumors negative for OCT4). In another study, LIN28 antibody was found to be a sensitive marker of ovarian primitive germ cell tumors like Gonadoblastomas, Dysgerminomas, Embryonal Carcinomas, and YSTs. LIN28 can be used to distinguish them from non- testicular germ cell tumors. High expression of Lin28 is associated with poor prognosis and high tumor aggressiveness in esophageal cancer and these effects are mediated through increased proliferation and invasiveness of esophageal cancer cells.
LIN28 antibody has been found to be a highly sensitive marker for testicular intratubular germ cell neoplasias, classic seminomas, embryonal carcinomas, and yolk sac tumors (YST) with relatively high specificity. LIN28 can be used as a test marker for these tumors and has demonstrated a similar level of test utility as SALL4. The major advantage of LIN28 over OCT4 is in identifying yolk sac tumors (yolk sac tumors negative for OCT4). In another study, LIN28 antibody was found to be a sensitive marker of ovarian primitive germ cell tumors like Gonadoblastomas, Dysgerminomas, Embryonal Carcinomas, and YSTs. LIN28 can be used to distinguish them from non- testicular germ cell tumors. High expression of Lin28 is associated with poor prognosis and high tumor aggressiveness in esophageal cancer and these effects are mediated through increased proliferation and invasiveness of esophageal cancer cells.
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Product Notes
The LIN28 (Catalog #AAA370440) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LIN28 (EP150) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "LIN28, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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