Dilution Information
Rabbit anti-Human MUSshi 2 Monoclonal Antibody | anti-MUSshi2 antibody
MUSshi 2 (RM422)
Reactivity
Human
Synonyms
MUSshi 2; Monoclonal Antibody; MUSshi 2 (RM422); musashi 2; anti-musashi 2; mushashi-2; anti-musashi-2; msi2; anti-msi2; anti-MUSshi2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RM422
Form/Format
Paraffin, Frozen
Musashi 2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Musashi 2 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the internal region of human Musashi 2.
Control
Testis, Kidney, Colon, Transitional Cell Carcinoma, Breast Cancer
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(Musashi 2 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tissue)
Immunohistochemistry (IHC)
(Musashi 2 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Tissue)
Related Product Information for anti-MUSshi2 antibody
Musashi-2 (MSI2) is an RNA-binding protein present in the cytoplasm of hematopoietic, neuronal progenitor, and stem cells. Musashi proteins have an RNA-recognition motif used to bind and stabilize mRNA in stem cell populations. MSI2 is also present in blood cells, astrocytes, and the development of reproductive cells in spermatogenesis and oogenesis.
Musashi 2 antibody can indicate the presence of stem cells in tumors of Colorectal, Lung, and Pancreatic Cancers, and in Glioblastoma, Leukemias, and xenografts, where it supports proliferation and prevents apoptosis. It's RNA-binding ability is increased in Leukemia cells over normal hematopoietic stem cells, and it's expression in Acute Myeloid Leukemia is associated with poor prognosis. MSI2 also has a role in promoting epithelial-to-mesenchymal transition, such as in Hepatocellular Carcinoma. MSI2-HOXA9 and other fusions/transformations are rare but MSI2 over-expression is found in almost all hematological disorders, and can be up-regulated further resulting in worse prognosis. Studies comparing normal cervical tissues have found that the expression of Musashi 2 is increased in cervical cancer tissues and may act as a prognostic biomarker in patients with cervical cancer. MSI2 has been found to be significantly upregulated in bladder cancer cells and tissues compared with normal bladder urothelial cells and tissues. IHC analysis has revealed high expression of Musashi 2 in bladder cancer specimens. It has been demonstrated that MSI2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valuable prognostic biomarker for bladder cancer patients.
Musashi 2 antibody can indicate the presence of stem cells in tumors of Colorectal, Lung, and Pancreatic Cancers, and in Glioblastoma, Leukemias, and xenografts, where it supports proliferation and prevents apoptosis. It's RNA-binding ability is increased in Leukemia cells over normal hematopoietic stem cells, and it's expression in Acute Myeloid Leukemia is associated with poor prognosis. MSI2 also has a role in promoting epithelial-to-mesenchymal transition, such as in Hepatocellular Carcinoma. MSI2-HOXA9 and other fusions/transformations are rare but MSI2 over-expression is found in almost all hematological disorders, and can be up-regulated further resulting in worse prognosis. Studies comparing normal cervical tissues have found that the expression of Musashi 2 is increased in cervical cancer tissues and may act as a prognostic biomarker in patients with cervical cancer. MSI2 has been found to be significantly upregulated in bladder cancer cells and tissues compared with normal bladder urothelial cells and tissues. IHC analysis has revealed high expression of Musashi 2 in bladder cancer specimens. It has been demonstrated that MSI2 can induce bladder cancer cell migration and invasion by activating the JAK2/STAT3 pathway, and may be a valuable prognostic biomarker for bladder cancer patients.
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Product Notes
The MUSshi2 (Catalog #AAA370506) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The MUSshi 2 (RM422) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "MUSshi 2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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