Mouse Cytokeratin 17 Monoclonal Antibody | anti-KRT17 antibody

Cytokeratin 17

Cat. Num. AAA370299

• Gene Names: KRT17; PC; K17; PC2; 39.1; CK-17; PCHC1
• Reactivity: Human, Rat, Goat and Pig
• Applications: Immunohistochemistry
• Synonyms: Cytokeratin 17; Monoclonal Antibody; anti-KRT17 antibody

• Host: Mouse
• Reactivity: Human, Rat, Goat and Pig
• Clonality: Monoclonal
• Isotype: IgG2a/K
• Form/Format: Cytokeratin 17 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
• Sequence Length: 432

• Applicable Applications for anti-KRT17 antibody: Immunohistochemistry (IHC) Formalin/Paraffin
• Localization: Cytoplasmic
• Control: Skin, Testis, Breast, Cervix, Cervical Carcinoma, Bladder TCC
• Intended Use: This antibody is intended for use in Immunohistochemical applications on formalinfixed paraffin-embedded tissues (FFPE), frozen tissue sections and cell preparations. Interpretation of results should be performed by a qualified medical professional.
• Immunogen: A synthetic peptide corresponding to human Cytokeratin 17 protein.
• Preparation and Storage: Store at 2 to 8 degree C in the dark.

Dilution Information

Immunohistochemistry (IHC)

(IHC of CK 17 on an FFPE Cervical Cancer Tissue)

Related Product Information for anti-KRT17 antibody

Cytokeratin 17 (CK 17) is a Type I cytokeratin with a MW of 46 kD found sometimes in association with Cytokeratin 7. Cytokeratin 17 is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to Jackson-Lawler type Pachyonychia Congenita and Steatocystoma Multiplex.Cytokeratin 17 antibody has been used to distinguish immature Cervical Squamous Metaplasia from High Grade Cervical Intraepithelial Neoplasia (CIN III). Anti-CK 17 also labels myoepithelial cells in the benign breast tissue. CK 17 can be useful when included in a panel of antibodies against TTF-1, napsin A, CK 5&6, p63, and SOX-2 for differentiation between lung adenocarcinoma (LADC) and lung squamous cell carcinoma (SCLC), especially for poorly-differentiated lung carcinoma. CK 17 is expressed in SCLC much higher than in LADC. In breast carcinomas, approximately 20% of patients show no expression of ER, PR and Her2, which are defined as triple negative tumor. Eighty-five percent of the triple negative breast carcinomas immunoreact with basal cytokeratins including anti-CK 17. The histologic differentiation of ampullary cancer, intestinal vs. pancreatobiliary, is very important for treatment. Usually anti-CK 17 and anti-MUC1 immunoreactivity represents pancreatobiliary subtype whereas anti-MUC2 and anti-CDX-2 positivity defines intestinal subtype.

NCBI and Uniprot Product Information

• NCBI GI #: 30379
• NCBI GeneID: 3872
• UniProt Accession #: Q04695; Q6IP98; Q8N1P6; A5Z1M9; A5Z1N0; A5Z1N1; A5Z1N2; A6NDV6; A6NKQ2
• Molecular Weight: 48,106 Da
• NCBI Official Full Name: cytokeratin 17
• NCBI Official Synonym Full Names: keratin 17
• NCBI Official Symbol: KRT17
• NCBI Official Synonym Symbols: PC; K17; PC2; 39.1; CK-17; PCHC1
• NCBI Protein Information: keratin, type I cytoskeletal 17
• UniProt Protein Name: Keratin, type I cytoskeletal 17
• Protein Family: Keratin
• UniProt Gene Name: KRT17
• UniProt Synonym Gene Names: CK-17; K17
• UniProt Entry Name: K1C17_HUMAN

NCBI Description

This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

Uniprot Description

K17: a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K6.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 17q21.2

Cellular Component: cytoplasm; intermediate filament

Molecular Function: MHC class II protein binding; MHC class II receptor activity; protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; hair follicle morphogenesis; intermediate filament organization; keratinization; positive regulation of cell growth; positive regulation of hair follicle development; positive regulation of translation; signal transduction

Disease: Pachyonychia Congenita 2; Steatocystoma Multiplex