Dilution Information
Mouse TDP-43/TARDBP Monoclonal Antibody | anti-TDP-43/TARDBP antibody
TDP-43/TARDBP (BSB-166)
Reactivity
Human, Mouse, Rat, Horse, Dog, Bovine
Synonyms
TDP-43/TARDBP; Monoclonal Antibody; TDP-43/TARDBP (BSB-166); tdp43; tdp-43; tdp 43; anti-tdp43; anti-tdp-43; anti-tdp 43; tardbp; anti-tardbp; transactive response dna binding protein 43; anti-TDP-43/TARDBP antibody
Host
Mouse
Reactivity
Human, Mouse, Rat, Horse, Dog, Bovine
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
BSB-166
Form/Format
Paraffin, Frozen
TDP-43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
TDP-43 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the N-terminus of the human TARDBP protein.
Control
Breast, Fallopian Tube, Tstis, Skin, Transition Call Carcinoma, Glioblastoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(TDP-43 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Immunohistochemistry (IHC)
(TDP-43 Antibody Immunohistochemistry on an FFPE Lung Adenocarcinoma Tissue)
Related Product Information for anti-TDP-43/TARDBP antibody
Transactive Response DNA binding protein 43 (TPD-43 or TARDBP) is an RNA and DNA binding protein in the heterogeneous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism.
TDP-43 antibody expression (TARDBP antibody) is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells. TDP-43/TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TDP-43/TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TDP-43/TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR-500a-3p. TDP-43/TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers. TDP-43/TARDBP has been found to be a novel oncogene in melanoma and regulates melanoma proliferation and metastasis potentially through modulation of glucose metabolism. TDP-43, has been found to promote triple-negative breast cancer (TNBC) progression.
TDP-43 antibody expression (TARDBP antibody) is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells. TDP-43/TARDBP regulation of miRNAs has both tumor supporting and suppressive roles. Upregulation of TDP-43/TARDBP can lead to continued autophagy for survival and suppression of apoptosis pathways, promoting cancer cell survival under conditions of nutrient stress, as was seen in a study of glioblastomas. TDP-43/TARDBP and its targeted miRNAs have been associated with increased cell growth and migration in hepatocellular and lung cancers, but also with tumor inhibition in rhabdomyosarcomas through miRNA miR-500a-3p. TDP-43/TARDBP may also influence the function and targets of MiR-152, and miRNA associated with hepatocellular carcinoma, endometrial, gastric, and ovarian cancers. TDP-43/TARDBP has been found to be a novel oncogene in melanoma and regulates melanoma proliferation and metastasis potentially through modulation of glucose metabolism. TDP-43, has been found to promote triple-negative breast cancer (TNBC) progression.
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Product Notes
The TDP-43/TARDBP (Catalog #AAA370541) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TDP-43/TARDBP (BSB-166) reacts with Human, Mouse, Rat, Horse, Dog, Bovine and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "TDP-43/TARDBP, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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