Related Product Information for Sorbitol Dehydrogenase assay kit
Sorbitol Dehydrogenase (SDH), also referred to as L-iditol dehydrogenase (EC 1.1.1.14) participates in the polyol pathway. Also known as the sorbitol-aldose pathway, this pathway is divided into two steps: first, glucose is reduced to sorbitol via the catalytic action of aldose reductase (AR), while the second step is catalyzed by sorbitol dehydrogenase, which utilizes sorbitol as substrate and subsequently produces fructose. Sorbitol is not a cell membrane permeable molecule; whereas fructose can be further metabolized inside the cells. Recent studies found that deficiency of Sorbitol Dehydrogenase causes the intracellular accumulation of sorbitol which leads complications in diabetes. The enzyme is predominately expressed in the liver cells and is only released into the bloodstream following acute liver damage. Therefore, the presence of significant SDH activity in serum is a potential indicator of liver injury or disease. SDH assay kit provides a quick and easy way for monitoring SDH activity in various samples. In this Assay, Sorbitol Dehydrogenase utilizes a provided substrate while reducing NAD+ to form NADH. NADH reacts with the developer, leading to the formation of a chromophore with strong absorbance at OD 450 nm. The assay is simple, sensitive and can detect Sorbitol Dehydrogenase Activity less than 50 uU in variety of samples
Product Categories/Family for Sorbitol Dehydrogenase assay kit
Product Notes
The Eukaryotes Sorbitol Dehydrogenase (Catalog #
AAA849774) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA849774 Assay Kit recognizes Eukaryotes Sorbitol Dehydrogenase.
It is sometimes possible for the material contained within the vial of
"Sorbitol Dehydrogenase, Assay Kit" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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