Testing Data
Human Aldose Reductase Assay Kit
Aldose Reductase Inhibitor Screening Kit (Colorimetric)
Reactivity
Human
Synonyms
Aldose Reductase; Aldose Reductase Inhibitor Screening Kit (Colorimetric); ALR2; Aldose Reductase Inhibitor Screening Kit; Aldose Reductase Inhibitor Kit (Colorimetric); AR; Aldose Reductase assay kit
Reactivity
Human
Detection Method
Absorbance: OD 340nm
Features & Benefits
Rapid
Simple, Sensitive, Reliable
Screening/characterizing Aldose Reductase inhibitors
Simple, Sensitive, Reliable
Screening/characterizing Aldose Reductase inhibitors
Preparation and Storage
Store at -20 degree C
Shelf life: ~12 months
Shelf life: ~12 months
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for Aldose Reductase assay kit
Aldose Reductase (aldehyde reductase; AR; ALR2; EC 1.1.1.21), a member of the aldo-keto reductase superfamily, catalyzes the NADPH-dependent reduction of a wide variety of aldoses (molecules containing carbonyl groups) to their corresponding alcohols. It is a key enzyme in the polyol pathway and the key factor in the reduction of glucose to sorbitol. Synthesis and accumulation of sorbitol due to AR activity is the main cause of diabetic complications, such as diabetic cataract, retinopathy, neuropathy and nephropathy. Inhibition of AR has been successfully used in clinical settings. These approved drugs prevent the accumulation of sorbitol. Thus, preventing eye and nerve damage in patients with diabetes. In addition, recent studies have shown that AR inhibitors may be able to prevent or delay the onset of cardiovascular complications such as ischemia/reperfusion injury, atherosclerosis and atherothrombosis. Aldose Reductase Inhibitor Screening Kit can be used to screen potential inhibitors of this molecular target. Epalrestat, a noncompetitive AR inhibitor, is used as a Positive Control. In this assay, AR activity is monitored by the reduction in absorbance reading at OD 340 nm, while potential inhibitors arrest this decrease. The kit is adapted to a 96-well format and provides a rapid, simple, sensitive and reliable test for screening of AR inhibitors.
Product Categories/Family for Aldose Reductase assay kit
Similar Products
Product Notes
The Human Aldose Reductase (Catalog #AAA849563) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA849563 Assay Kit recognizes Human Aldose Reductase. It is sometimes possible for the material contained within the vial of "Aldose Reductase, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
