IL-17RB active protein

Recombinant human IL-17RB protein

Cat. Num. AAA201352

• Gene Names: IL17RB; CRL4; EVI27; IL17BR; IL17RH1
• Applications: SDS-Page
• Purity: >85% by SDS-PAGE
• Synonyms: IL-17RB; Recombinant human IL-17RB protein; Interleukin-17 receptor B; CRL4; EVI27; IL17BR; IL17RH1; IL-17 receptor B; Cytokine receptor-like 4; IL-17 receptor homolog 1; Interleukin-17B receptor; IL-17RB active protein

• Host: Baculovirus
• Purity/Purification: >85% by SDS-PAGE
• Form/Format: Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
• Concentration: 0.25mg/ml (determined by Bradford assay) (varies by lot)
• Sequence Positions: 18-292aa
• Sequence: REPTVQCGSE TGPSPEWMLQ HDLIPGDLRD LRVEPVTTSV ATGDYSILMN VSWVLRADAS IRLLKATKIC VTGKSNFQSY SCVRCNYTEA FQTQTRPSGG KWTFSYIGFP VELNTVYFIG AHNIPNANMN EDGPSMSVNF TSPGCLDHIM KYKKKCVKAG SLWDPNITAC KKNEETVEVN FTTTPLGNRY MALIQHSTII GFSQVFEPHQ KKQTRASVVI PVTGDSEGAT VQLTPYFPTC GSDCIRHKGT VVLCPQTGVP FPLDNNKSKP GGWLP

• Applicable Applications for IL-17RB active protein: SDS-PAGE, Bioactivity
• Endotoxin: <1 EU per 1ug of protein (determined by LAL method)
• Species: Human
• Tag: hIgG-His-Tag
• Predicted N-term: Arg18
• Bioactivity: Measured by its binding ability in a functional ELISA with Human IL25. The ED50 range <= 2ug/ml.
• Preparation and Storage: Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.

SDS-Page

(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain)

Biological Activity

(Human IL25 (CAT# ATGP4018) is coated at 2 ug/ml (100 ul/well) can bind Human IL17RB. The ED50 range )

Related Product Information for IL-17RB active protein

IL-17RB, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17A or IL17C. It has been shown to mediate the activation of NFkappaB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. Recombinant human IL-17RB, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for IL-17RB active protein

Immunology; Proteins

References

Ma XJ,. et al. (2006) J Clin Oncol. 24:4611-4619. Schwandner R,. et al. (2000) J. Exp. Med. 191:1233-1240.

NCBI and Uniprot Product Information

• NCBI GI #: 27477074
• NCBI GeneID: 55540
• NCBI Accession #: NP_061195.2
• NCBI GenBank Nucleotide #: NM_018725.3
• UniProt Accession #: Q9NRM6; Q9BPZ0; Q9NRL4; Q9NRM5
• Molecular Weight: 31,773 Da
• NCBI Official Full Name: interleukin-17 receptor B
• NCBI Official Synonym Full Names: interleukin 17 receptor B
• NCBI Official Symbol: IL17RB
• NCBI Official Synonym Symbols: CRL4; EVI27; IL17BR; IL17RH1
• NCBI Protein Information: interleukin-17 receptor B
• UniProt Protein Name: Interleukin-17 receptor B
• UniProt Gene Name: IL17RB
• UniProt Synonym Gene Names: CRL4; EVI27; IL17BR; IL-17 receptor B; IL-17RB; IL-17Rh1; IL17Rh1; IL-17B receptor
• UniProt Entry Name: I17RB_HUMAN

Uniprot Description

IL17RB: Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: interleukin-17 receptor activity

Biological Process: defense response