SDS-Page
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
)
CD200 active protein
Recombinant human CD200 protein
Gene Names
CD200; MRC; MOX1; MOX2; OX-2
Applications
SDS-Page
Purity
>95% by SDS-PAGE
Synonyms
CD200; Recombinant human CD200 protein; OX-2 membrane glycoprotein isoform a; MOX1; MOX2; MRC; OX-2; CD200 active protein
Host
Baculovirus
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid. In Phosphate-Buffered Saline (pH7.4) containing 10% glycerol
Concentration
0.5mg/ml (determined by Absorbance at 280nm) (varies by lot)
Sequence Positions
31-232aa
Sequence
Applicable Applications for CD200 active protein
SDS-PAGE, Bioactivity
Endotoxin
<1 EU per 1ug of protein (determined by LAL method)
Species
Human
Tag
His-Tag
Predicted N-term
Ala
Bioactivity
Measured by its binding ability in a functional ELISA with Human CD200R1
Preparation and Storage
Can be stored at +2C to +8 degree C for 1 week. For long term storage, aliquot and store at -20C to -80 degree C. Avoid repeated freezing and thawing cycles.
SDS-Page
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain. )
SDS-Page
(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.
)
Biological Activity
(CD200 Subunit is coated at 10 ug/ml (100 ul/well) can bind Human CD200R1 (CAT# ATGP3809) in a Functional ELISA assay.)
Biological Activity
(CD200 Subunit is coated at 10 ug/ml (100 ul/well) can bind Human CD200R1 (CAT# ATGP3809) in a Functional ELISA assay.)
Related Product Information for CD200 active protein
CD200, also known as OX-2 membrane glycoprotein isoform a, belongs to the immunoglobulin superfamily. This protein imparts immune privileges by suppressing alloimmune and autoimmune responses through its receptor, CD200R, expressed primarily on myeloid cells. D200 and CD200R associate via their respective N-terminal Ig-like domains. CD200-CD200R signaling have been shown to play an important role in the regulation of anti-tumor immunity, and overexpression of CD200 has been reported in a number of malignancies, including CLL, as well as on cancer stem cells. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Elevated expression of this protein has been reported to be associated with poor prognosis in a number of human malignancies. In addition, it also plays an important role in prevention of graft rejection, autoimmune diseases and spontaneous abortion. Recombinant human CD200 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for CD200 active protein
References
Akkaya M., et al. (2013) PLoS One. 8:e63325. Li L., et al. (2016) Med Sci Monit. 22:1079-1084.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
24.8kDa (225aa)
NCBI Official Full Name
OX-2 membrane glycoprotein isoform a
NCBI Official Synonym Full Names
CD200 molecule
NCBI Official Symbol
CD200
NCBI Official Synonym Symbols
MRC; MOX1; MOX2; OX-2
NCBI Protein Information
OX-2 membrane glycoprotein
UniProt Protein Name
OX-2 membrane glycoprotein
Protein Family
UniProt Gene Name
CD200
UniProt Synonym Gene Names
MOX1; MOX2
NCBI Description
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Description
Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.
Research Articles on CD200
Similar Products
Product Notes
The CD200 cd200 (Catalog #AAA201326) is an Active Protein produced from Baculovirus and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 31-232aa. AAA Biotech's CD200 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, Bioactivity. Researchers should empirically determine the suitability of the CD200 cd200 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below:Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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