Dilution Information
Mouse Trop-2/EGP-1 Monoclonal Antibody | anti-Trop-2/EGP-1 antibody
Trop-2/EGP-1 (BSB-148)
Reactivity
Human, Mouse, Rat
Synonyms
Trop-2/EGP-1; Monoclonal Antibody; Trop-2/EGP-1 (BSB-148); trop-2; trop2; anti-trop-2; anti-trop2; egp-1; egp1; anti-egp-1; anti-egp1; anti-Trop-2/EGP-1 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-148
Form/Format
Paraffin, Frozen
Anti-Trop-2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Anti-Trop-2 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the extracellular domain of the human TROP-2 protein.
Control
Breast, Prostate, Skin, Transitional Cell Carcinoma, Papillary Thyroid Carcinoma, Pancreatic Carcinoma
Localization
Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(Trop-2 Antibody Immunohistochemistry on an FFPE Pancreatic Adenocarcinoma Tissue)
Immunohistochemistry (IHC)
(Trop-2 Antibody Immunohistochemistry on an FFPE Pancreatic Adenocarcinoma Tissue)
Related Product Information for anti-Trop-2/EGP-1 antibody
Trop-2 or Tumor-associated calcium signal transducer 2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This transmembrane glycoprotein functions in a variety of cell signaling pathways and was first elucidated as a transducer of an intracellular calcium signal. Trop-2 expression has been demonstrated to depend on a large variety of transcription factors. Trop-2 is involved in several cell signaling pathways, of which many are associated with tumorigenesis.
In Thyroid Cancer cell invasion, Trop-2 signal transduction has been seen as a downstream effect of the ERK and JNK pathways, where its signaling enhances stem cell-like properties of cancer cells, as Trop-2 regulates proliferation and self-renewal through-catenin signaling. In a study, the majority of Papillary Thyroid Carcinoma (PTC) specimens were positive for Trop-2; however, the pattern of staining differed significantly between the histopathological variants. All Papillary microcarcinomas (mPTC), PTC classic variant (PTC cv), and tall cell variants (PTC tcv) were Trop-2 positive, with mainly diffuse staining. In contrast, less than half of the PTC follicular variant specimens were positive for Trop-2, with only focal immunoreactivity. Trop-2 may play a role in tumor progression given the involvement in several molecular pathways traditionally associated with cancer development. High Trop-2 antibody expression correlates with poor prognosis in Pancreatic Carcinoma, Hilar Cholangiocarcinoma, Cervical Cancer, Gastric Cancer, and others. Increased Trop-2 antibody expression has been associated with poor overall and disease-free survival outcomes across several solid tumors. Given Trop-2's expression pattern and associated poor prognostic outcomes, Trop-2 is a rational prognostic marker and a possible therapeutic target.
In Thyroid Cancer cell invasion, Trop-2 signal transduction has been seen as a downstream effect of the ERK and JNK pathways, where its signaling enhances stem cell-like properties of cancer cells, as Trop-2 regulates proliferation and self-renewal through-catenin signaling. In a study, the majority of Papillary Thyroid Carcinoma (PTC) specimens were positive for Trop-2; however, the pattern of staining differed significantly between the histopathological variants. All Papillary microcarcinomas (mPTC), PTC classic variant (PTC cv), and tall cell variants (PTC tcv) were Trop-2 positive, with mainly diffuse staining. In contrast, less than half of the PTC follicular variant specimens were positive for Trop-2, with only focal immunoreactivity. Trop-2 may play a role in tumor progression given the involvement in several molecular pathways traditionally associated with cancer development. High Trop-2 antibody expression correlates with poor prognosis in Pancreatic Carcinoma, Hilar Cholangiocarcinoma, Cervical Cancer, Gastric Cancer, and others. Increased Trop-2 antibody expression has been associated with poor overall and disease-free survival outcomes across several solid tumors. Given Trop-2's expression pattern and associated poor prognostic outcomes, Trop-2 is a rational prognostic marker and a possible therapeutic target.
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Product Notes
The Trop-2/EGP-1 (Catalog #AAA370519) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Trop-2/EGP-1 (BSB-148) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Trop-2/EGP-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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