Dilution Information
Rabbit anti-Human TIA-1 Monoclonal Antibody | anti-TIA-1 antibody
TIA-1 (RBT-TIA1)
Reactivity
Human
Synonyms
TIA-1; Monoclonal Antibody; TIA-1 (RBT-TIA1); tia-1; anti-tia-1; tia1m anti-tia; tia; anti-tia; t-cell intracytoplasmic antigen; anti-t-cell; anti-TIA-1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-TIA1
Form/Format
Paraffin, Frozen
TIA-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
TIA-1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant fragment corresponding to the N Terminus of the human TIA1.
Control
Tonsil, Spleen, Anaplastic Large Cell Lymphoma
Localization
Cytoplasmic
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(TIA-1 Antibody Immunohistochemistry on an FFPE CLL/SLL Lymphoma Tissue)
Immunohistochemistry (IHC)
(TIA-1 Antibody Immunohistochemistry on an FFPE CLL/SLL Lymphoma Tissue)
Related Product Information for anti-TIA-1 antibody
TIA-1 (T-cell intracytoplasmic antigen) is a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing.
The expression of TIA-1 antibody has been studied in anaplastic large cell lymphomas (ALCL), NK-cell lymphomas, peripheral T-cell lymphomas, T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, and Hodgkin's lymphoma, etc. Studies show that 60 to 70% of anaplastic large cell lymphomas react with TIA-1. TIA-1 also reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T-or NK-phenotype. All B-cell lymphomas, Hodgkin's and lymphoblastic leukemias are negative for TIA-1 antibody.
The expression of TIA-1 antibody has been studied in anaplastic large cell lymphomas (ALCL), NK-cell lymphomas, peripheral T-cell lymphomas, T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, and Hodgkin's lymphoma, etc. Studies show that 60 to 70% of anaplastic large cell lymphomas react with TIA-1. TIA-1 also reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T-or NK-phenotype. All B-cell lymphomas, Hodgkin's and lymphoblastic leukemias are negative for TIA-1 antibody.
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Product Notes
The TIA-1 (Catalog #AAA370547) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIA-1 (RBT-TIA1) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "TIA-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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