Testing Data
G-protein coupled receptor 119 (GPR119) Cell Line | GPR119 cell line
Human G protein-coupled receptor 119 (GPR119) ACTOne Stable Cell Line
Gene Names
GPR119; GPCR2
Synonyms
G-protein coupled receptor 119 (GPR119); Human G protein-coupled receptor 119 (GPR119) ACTOne Stable Cell Line; GPR119 cell line
Sequence Length
335
Application Notes
cAMP dependent human GPR119 cell-based assay
cell-based high-throughput screening of human GPR119 agonists/antagonists.
cell-based high-throughput screening of human GPR119 agonists/antagonists.
Growth Properties
Adherent
Detection
FlexStation or Microplate reader
Shipping Note
Product available only in the USA.
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for GPR119 cell line
Introduction: GPR119, expressed in the pancreas and gastrointestinal tract, encodes a member of the rhodopsin subfamily of Gprotein-coupled receptors. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.
Description: Human GPR119 ACTOne is a HEK293-CNG cell line that expresses recombinant human GPR119. HEK293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization which can be easily measured with fluorescent Membrane Potential Dye (Cat# MBS430187). The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR, or a fluorescence microplate reader.
Description: Human GPR119 ACTOne is a HEK293-CNG cell line that expresses recombinant human GPR119. HEK293-CNG cells express a modified CNG (Cyclic Nucleotide Gated) channel that opens in response to elevated intracellular cAMP levels and consequently result in ion flux and cell membrane depolarization which can be easily measured with fluorescent Membrane Potential Dye (Cat# MBS430187). The assay allows both end-point and kinetic measurement of intracellular cAMP changes with a FLIPR, or a fluorescence microplate reader.
Product Categories/Family for GPR119 cell line
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
36,889 Da
NCBI Official Synonym Full Names
G protein-coupled receptor 119
NCBI Official Symbol
GPR119
NCBI Official Synonym Symbols
GPCR2
NCBI Protein Information
glucose-dependent insulinotropic receptor
UniProt Protein Name
Glucose-dependent insulinotropic receptor
Protein Family
UniProt Gene Name
GPR119
NCBI Description
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
Uniprot Description
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Research Articles on GPR119
Similar Products
Product Notes
The GPR119 gpr119 (Catalog #AAA430275) is a Cell Line and is intended for research purposes only. The product is available for immediate purchase. cAMP dependent human GPR119 cell-based assay cell-based high-throughput screening of human GPR119 agonists/antagonists. Researchers should empirically determine the suitability of the GPR119 gpr119 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "G-protein coupled receptor 119 (GPR119), Cell Line" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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