Rabbit anti-Human, Rat TREK1 Polyclonal Antibody | anti-Kcnk2 antibody

TREK1 (Twik-Related Potassium Channel 1, Kcnk2)

Cat. Num. AAA614739

• Gene Names: Kcnk2; TREK-1; AI848635; A430027H14Rik
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: TREK1; Polyclonal Antibody; TREK1 (Twik-Related Potassium Channel 1; Kcnk2); Anti -TREK1 (Twik-Related Potassium Channel 1; anti-Kcnk2 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human TREK1. Species Crossreactivity
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.025% sodium azide before the addition of glycerol to 40%.

• Applicable Applications for anti-Kcnk2 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:200 Rat brain membranes
• Immunogen: Synthetic peptide corresponding to aa8-28, DPKSA AQNSK PRLSF STKC, of human TREK-1 (Accession numbers AAF89743, AAD47569). Epitope location: Intracellular, N-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Kcnk2 antibody

TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.

Product Categories/Family for anti-Kcnk2 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 55274229
• NCBI GeneID: 16526
• UniProt Accession #: Q4VQI2; P97438; Q6P6P9
• Molecular Weight: 46,844 Da
• NCBI Official Full Name: TREK1
• NCBI Official Synonym Full Names: potassium channel, subfamily K, member 2
• NCBI Official Symbol: Kcnk2
• NCBI Official Synonym Symbols: TREK-1; AI848635; A430027H14Rik
• NCBI Protein Information: potassium channel subfamily K member 2; TREK-1 K(+) channel subunit; two pore potassium channel TPKC1; outward rectifying potassium channel protein TREK-1
• UniProt Protein Name: TREK1
• Protein Family: Potassium channel subfamily
• UniProt Gene Name: Kcnk2
• UniProt Entry Name: Q4VQI2_MOUSE

Uniprot Description

TREK-1: Outward rectifying potassium channel. Homodimer (Potential). Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Channel, potassium; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; membrane; endoplasmic reticulum; plasma membrane; integral to membrane

Molecular Function: protein binding; voltage-gated potassium channel activity; potassium channel activity; outward rectifier potassium channel activity; potassium ion leak channel activity; voltage-gated ion channel activity; potassium channel inhibitor activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of membrane potential; transport; ion transport; potassium ion transport; stabilization of membrane potential