Testing Data
(Detection of TREK 1 in human brain membrane lysate.)
Rabbit anti-Human TREK1 Polyclonal Antibody | anti-Kcnk2 antibody
TREK1 (Twik-Related Potassium Channel 1, Kcnk2)
Gene Names
Kcnk2; TREK-1; AI848635; A430027H14Rik
Reactivity
Human
Applications
Western Blot
Purity
Affinity PurifiedPurified by affinity chromatography
Synonyms
TREK1; Polyclonal Antibody; TREK1 (Twik-Related Potassium Channel 1; Kcnk2); Anti -TREK1 (Twik-Related Potassium Channel 1; anti-Kcnk2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human TREK 1. Species Seqeuence Homology: mouse, bovine; 100%, rat; 88%
Purity/Purification
Affinity Purified
Purified by affinity chromatography
Purified by affinity chromatography
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide
Applicable Applications for anti-Kcnk2 antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Dilution: Western Blot: 2ug/ml. Esssential to run against membrane preps.
Dilution: Western Blot: 2ug/ml. Esssential to run against membrane preps.
Immunogen
Synthetic peptide corresponding to aa1-100 from the N-terminal region of human TREK1 (Swiss-Prot# Q9NRT2).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Testing Data
(Detection of TREK 1 in human brain membrane lysate.)
Testing Data
(Detection of TREK 1 in human brain membrane lysate.)
Related Product Information for anti-Kcnk2 antibody
TREK-1 is a two-pore-domain background potassium channel expressed throughout the central nervous system. It is opened by polyunsaturated fatty acids and lysophospholipids. As well, it is regulated by various neurotransmitters. It has been shown that alterations in the functioning, regulation, or both of the TREK-1 channel may alter mood. TREK-1 is also activated by volatile anesthetics and has been suggested to be an important target in the action of these drugs. Therefore, this particular K+ channel emerges as a potential innovative target for developing new therapeutic agents for anesthesiology and neurology, such as antidepressants.
Product Categories/Family for anti-Kcnk2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
46,844 Da
NCBI Official Full Name
TREK1
NCBI Official Synonym Full Names
potassium channel, subfamily K, member 2
NCBI Official Symbol
Kcnk2
NCBI Official Synonym Symbols
TREK-1; AI848635; A430027H14Rik
NCBI Protein Information
potassium channel subfamily K member 2; TREK-1 K(+) channel subunit; two pore potassium channel TPKC1; outward rectifying potassium channel protein TREK-1
UniProt Protein Name
TREK1
Protein Family
UniProt Gene Name
Kcnk2
UniProt Entry Name
Q4VQI2_MOUSE
Uniprot Description
TREK-1: Outward rectifying potassium channel. Homodimer (Potential). Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass
Cellular Component: voltage-gated potassium channel complex; membrane; endoplasmic reticulum; plasma membrane; integral to membrane
Molecular Function: protein binding; voltage-gated potassium channel activity; potassium channel activity; potassium ion leak channel activity; outward rectifier potassium channel activity; voltage-gated ion channel activity; potassium channel inhibitor activity
Biological Process: G-protein coupled receptor protein signaling pathway; regulation of membrane potential; transport; ion transport; stabilization of membrane potential; potassium ion transport
Research Articles on Kcnk2
Similar Products
Product Notes
The Kcnk2 kcnk2 (Catalog #AAA613545) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TREK1 (Twik-Related Potassium Channel 1, Kcnk2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TREK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 2ug/ml. Esssential to run against membrane preps. Researchers should empirically determine the suitability of the Kcnk2 kcnk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TREK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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