Rabbit anti-Human, Rat K2P2.1 Polyclonal Antibody | anti-K2P2.1 antibody

Anti-K2P2.1 (TREK-1) Antibody

Cat. Num. AAA4159242

• Gene Names: KCNK2; TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: Affinity Purified On Immobilized Antigen.
• Synonyms: K2P2.1; Polyclonal Antibody; Anti-K2P2.1 (TREK-1) Antibody; K 2P2-1 (TREK-1); anti-K2P2.1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Specificity: Mouse-17/18 residues identical.
• Purity/Purification: Affinity Purified On Immobilized Antigen.
• Form/Format: Liquid; PBS, pH 7.4 with 0.05% sodium azide.
• Concentration: 0.8ug/ul (varies by lot)
• Sequence Length: 426

• Applicable Applications for anti-K2P2.1 antibody: Western Blot (WB)
• Application Notes: WB: Rat brain membranes (1:200)
• Immunogen: Peptide DPKSAAQNSKPRLSFSTK(C), corresponding to residues 8-25 of human K2P2.1 (TREK-1) (Accession Q9NRT2).
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.; For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-K2P2.1 antibody

Twik-Related K+ Channel 1, Kcnk2 K2P2.1 (also named TWIK-Related K+ channel, TREK-1 or KCNK2) is a member of the 2-pore (2P) domain K+ channels family that includes at least 16 members. These channels show little time or voltage dependence and are considered to be-leak-or-background-K+ channels, thereby generating background currents which help set the membrane resting potential and cell excitation. The K2P channels have a signature topology that includes four transmembrane domains and two pore domains with intracellular N-and C termini. K2P channels are regulated by diverse physical and chemical stimuli including temperature, changes in intracellular pH, mechanical stretch, inhalation anesthetics, etc. The channels can then be subclassified based in their specific activators. K2P2.1 can be integrated to a K2P subfamily that includes K2P4.1 (TRAAK) and K2P10.1 (TREK2) that are activated by intracellular unsaturated fatty acids such as arachidonic acid, lysophosphatidic acid and mechanical stretch. In addition, K2P2.1 can also be activated by general anesthetics such as halothane and chloroform and intracellular acidification. K2P2.1 expression in humans is largely restricted to the brain with some expression in ovary and small intestine while K2P2.1expression in rodents is more widespread. Recently, it has been shown that K2P2.1 has an important role in mood regulation, as knockout mice show resistance to depression, suggesting that K2P2.1 may be a potential target for anti-depressants.

NCBI and Uniprot Product Information

• NCBI GI #: 121078693
• NCBI GeneID: 3776
• NCBI Official Full Name: K2P2.1 potassium channel
• NCBI Official Synonym Full Names: potassium two pore domain channel subfamily K member 2
• NCBI Official Symbol: KCNK2
• NCBI Official Synonym Symbols: TREK; TPKC1; TREK1; K2p2.1; TREK-1; hTREK-1c; hTREK-1e
• NCBI Protein Information: potassium channel subfamily K member 2

NCBI Description

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]