Rabbit anti-Human RP105 Polyclonal Antibody | anti-RP105 antibody

RP105 Antibody

Cat. Num. AAA9402010

• Gene Names: CD180; LY64; Ly78; RP105
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity chromatography purified via peptide column
• Synonyms: RP105; Polyclonal Antibody; RP105 Antibody; Radioprotective 105; Lymphocyte antigen 64; CD180 antigen precursor; anti-RP105 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity chromatography purified via peptide column
• Form/Format: Supplied in PBS containing 0.02% sodium azide.
• Sequence Length: 661

• Applicable Applications for anti-RP105 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen Type: Peptide
• Immunogen Description: Raised against a 11 amino acid peptide from near the amino terminus of human RP105.
• Target Name: RP105
• Preparation and Storage: Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of RP105 in human spleen tissue lysate with RP105 antibody at (A) 0.5 and (B) 1 ug/mL.)

Immunohistochemistry (IHC)

(Immunohistochemistry of RP105 in human spleen tissue with RP105 antibody at 2 ug/mL.)

Related Product Information for anti-RP105 antibody

Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins. One such protein is RP105, a recently identified homolog to TLR4 that, with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. It has also been suggested that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.

Product Categories/Family for anti-RP105 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 1843411
• NCBI GeneID: 4064
• Molecular Weight: 74,179 Da
• NCBI Official Full Name: RP105
• NCBI Official Synonym Full Names: CD180 molecule
• NCBI Official Symbol: CD180
• NCBI Official Synonym Symbols: LY64; Ly78; RP105
• NCBI Protein Information: CD180 antigen
• UniProt Protein Name: CD180 antigen
• UniProt Gene Name: CD180
• UniProt Synonym Gene Names: LY64; RP105
• UniProt Entry Name: CD180_HUMAN

NCBI Description

CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]

Uniprot Description

CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q12

Cellular Component: plasma membrane; integral to membrane

Biological Process: positive regulation of lipopolysaccharide-mediated signaling pathway; innate immune response; inflammatory response; B cell proliferation during immune response