Rabbit Eph Receptor A6 Polyclonal Antibody | anti-Epha6 antibody

Eph Receptor A6 Antibody (C-term)

Cat. Num. AAA9211876

• Reactivity: Human, mouse (Predicted Reactivity: Rat)
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: Eph Receptor A6; Polyclonal Antibody; Eph Receptor A6 Antibody (C-term); Ephrin type-A receptor 6; EPH homology kinase 2; EHK-2; Epha6; Ehk-2; Ehk2; anti-Epha6 antibody

• Host: Rabbit
• Reactivity: Human, mouse (Predicted Reactivity: Rat)
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This Eph Receptor A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1006-1035 amino acids from the C-terminal region of human Eph Receptor A6.
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Sequence Positions: 1006-1035
• Sequence Length: 1035

• Applicable Applications for anti-Epha6 antibody: ELISA (EIA), Immunohistochemistry (IHC-P) Western Blot (WB)
• Application Notes: WB~~1:1000; IHC-P~~1:50~100
• Cellular location: Membrane; Single-pass type 1 membrane protein.
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Immunohistochemistry (IHC)

(Eph receptor A6 (EPHA6) Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the Eph receptor A6 (EPHA6) Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Western Blot (WB)

(Western blot analysis of Eph receptor A6 (EPHA6) Antibody (C-term) in mouse stomach tissue lysates (35ug/lane). EPHA6 (arrow) was detected using the purified Pab.)

Related Product Information for anti-Epha6 antibody

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).

Product Categories/Family for anti-Epha6 antibody

Cardiovascular; Neuroscience

References

Lee, A.M., et al., DNA Cell Biol. 15(10):817-825 (1996).

NCBI and Uniprot Product Information

• NCBI GI #: 341940657
• UniProt Accession #: Q62413; Q8CCN2; B9EIV2
• NCBI Official Full Name: Ephrin type-A receptor 6
• UniProt Protein Name: Ephrin type-A receptor 6
• Protein Family: Ephrin type-A receptor
• UniProt Gene Name: Epha6
• UniProt Synonym Gene Names: Ehk-2; Ehk2; EHK-2
• UniProt Entry Name: EPHA6_MOUSE

Uniprot Description

EphA6: Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; EC 2.7.10.1; TK group; Eph family

Cellular Component: nucleoplasm; membrane; integral to plasma membrane; integral to membrane

Molecular Function: transferase activity; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: ephrin receptor signaling pathway; phosphorylation; protein amino acid phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway