Rabbit anti-Human Paralemmin3 Polyclonal Antibody | anti-PALM3 antibody

Paralemmin3 Antibody

Cat. Num. AAA151518

• Reactivity: Human
• Applications: ELISA, Western Blot, Immunocytochemistry, Immunofluorescence
• Purity: Paralemmin3 Antibody is affinity chromatography purified via peptide column.
• Synonyms: Paralemmin3; Polyclonal Antibody; Paralemmin3 Antibody; Paralemmin-3; paralemmin 3; anti-PALM3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of Paralemmin3 are known to exist; this antibody will only detect the longer isoform
• Purity/Purification: Paralemmin3 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 673

• Applicable Applications for anti-PALM3 antibody: ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
• Application Notes: Paralemmin3 antibody can be used for detection of Paralemmin3 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: Paralemmin3 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human Paralemmin3.
• Buffer: Paralemmin3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: Paralemmin3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of Paralemmin3 in MCF7 cell lysate with Paralemmin3 antibody at 1 μg/mL.)

Immunocytochemistry (IHC)

(Immunocytochemistry of Paralemmin 3 in MCF7 cells with Paralemmin 3 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of Paralemmin 3 in MCF7 cells with Paralemmin 3 antibody at 20 μg/mL.)

Related Product Information for anti-PALM3 antibody

Paralemmin3 Antibody: Paralemmin3 is a recently identified protein that associates with the single immunoglobulin IL-1 receptor-related molecule (SIGIRR), a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Silencing of Paralemmin3 expression by RNAi inhibited the release of inflammatory cytokines in A549 cells after stimulation with lipopolysaccharide (LPS), suggesting Paralemmin3 may function as an adaptor in the LPS-TLR4 signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 222537747
• NCBI GeneID: 342979
• NCBI Accession #: NP_001138500
• NCBI GenBank Nucleotide #: NM_001145028.1
• UniProt Accession #: A6NDB9
• Molecular Weight: 71,695 Da
• NCBI Official Full Name: paralemmin-3
• NCBI Official Synonym Full Names: paralemmin 3
• NCBI Official Symbol: PALM3
• NCBI Protein Information: paralemmin-3
• UniProt Protein Name: Paralemmin-3
• Protein Family: Paralemmin
• UniProt Gene Name: PALM3
• UniProt Entry Name: PALM3_HUMAN

Uniprot Description

PALM3: ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling. Belongs to the paralemmin family.

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: cytoplasm; plasma membrane

Molecular Function: protein binding; ATP binding

Biological Process: negative regulation of cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide; Toll signaling pathway