Rabbit TMEM88 Polyclonal Antibody | anti-TMEM88 antibody

TMEM88 Antibody

Cat. Num. AAA151139

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: TMEM88 Antibody is affinity chromatography purified via peptide column.
• Synonyms: TMEM88; Polyclonal Antibody; TMEM88 Antibody; TMEM88A; Transmembrane protein 88; transmembrane protein 88; anti-TMEM88 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: At least two isoforms of TMEM88 are known to exist; this antibody will recognize both isoforms.
• Purity/Purification: TMEM88 Antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 159

• Applicable Applications for anti-TMEM88 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: TMEM88 antibody can be used for detection of TMEM88 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: TMEM88 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human TMEM88.
• Buffer: TMEM88 Antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: TMEM88 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of TMEM88 in human brain tissue lysate with TMEM88 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.)

Immunohistochemistry (IHC)

(Immunohistochemistry of TMEM88 in mouse brain tissue with TMEM88 antibody at 2.5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of TMEM88 in mouse brain tissue with TMEM88 antibody at 20 μg/mL.)

Related Product Information for anti-TMEM88 antibody

TMEM88 Antibody: Transmembrane protein 88 (TMEM88) is a two-transmembrane-type protein whose C-terminal tail has been shown to bind the PDZ domain of Dishevelled (Dvl), one of the key components in Wnt signaling pathways. TMEM88 attentuated the Wnt/beta-catenin signaling induced by Wnt-1 ligand in a dose-dependent manner and knockdown of TMEM88 by RNAi increased Wnt activity, suggesting that TMEM88 plays a role in regulating Wnt signaling in a context-dependent manner.

NCBI and Uniprot Product Information

• NCBI GI #: 44662813
• NCBI GeneID: 92162
• NCBI Accession #: EAW90125
• NCBI GenBank Nucleotide #: NM_203411.1
• UniProt Accession #: Q6PEY1
• Molecular Weight: 17,251 Da
• NCBI Official Full Name: transmembrane protein 88
• NCBI Official Synonym Full Names: transmembrane protein 88
• NCBI Official Symbol: TMEM88
• NCBI Protein Information: transmembrane protein 88
• UniProt Protein Name: Transmembrane protein 88
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM88
• UniProt Synonym Gene Names: TMEM88A
• UniProt Entry Name: TMM88_HUMAN

Uniprot Description

TMEM88: Belongs to the TMEM88 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: plasma membrane; integral to membrane

Biological Process: Wnt receptor signaling pathway; multicellular organismal development