Western Blot (WB)
(Western blot analysis of CADM3 in human brain tissue lysate with CADM3 antibody at (A) 1 and (B) 2 μg/ml.)
Rabbit CADM3 Polyclonal Antibody | anti-CADM3 antibody
CADM3 Antibody
Gene Names
CADM3; BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
Purity
CADM3 antibody is affinity chromatography purified via peptide column.
Synonyms
CADM3; Polyclonal Antibody; CADM3 Antibody; Cell adhesion molecule 3; BIgR; NECL1; Necl-1; TSLL1; IGSF4B; synCAM3; cell adhesion molecule 3; anti-CADM3 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
CADM3 antibody is human, mouse and rat reactive. At least three isoforms are known to exist; this antibody will only detect the two longest isoforms. CADM3 antibody is predicted to not cross-react with other members of the CADM protein family.
Purity/Purification
CADM3 antibody is affinity chromatography purified via peptide column.
Form/Format
Liquid
Concentration
1 mg/mL (varies by lot)
Sequence Length
432
Applicable Applications for anti-CADM3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
CADM3 antibody can be used for detection of CADM3 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
Conjugate
Unconjugated
Immunogen
CADM3 antibody was raised against a 16 amino acid peptide near the center of human CADM3.
Buffer
CADM3 antibody is supplied in PBS containing 0.02% sodium azide.
Preparation and Storage
CADM3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
Western Blot (WB)
(Western blot analysis of CADM3 in human brain tissue lysate with CADM3 antibody at (A) 1 and (B) 2 μg/ml.)
Western Blot (WB)
(Western blot analysis of CADM3 in human brain tissue lysate with CADM3 antibody at (A) 1 and (B) 2 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of CADM3 in mouse brain tissue with CADM3 antibody at 5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of CADM3 in mouse brain tissue with CADM3 antibody at 5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of CADM3 in mouse brain tissue with CADM3 antibody at 20 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of CADM3 in mouse brain tissue with CADM3 antibody at 20 μg/ml.)
Related Product Information for anti-CADM3 antibody
Cell adhesion molecule 3 (CADM3) is a member of a family of immunoglobulin-like, calcium-independent cell-cell adhesion molecules (1,2). CADM3 localizes to non-junctional contact sites of presynaptic nerve terminals, axons and glia cell processes and is thought to play an important role in the formation of synapses, axon bundles and myelinated axons (3). Recently, CADM3 has been shown to suppress the growth and tumorigenic ability of colon cancer cells, indicating that it can act as a tumor suppressor (4).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Predicted: 44; 48 kDa
Observed: 44 kDa
Observed: 44 kDa
NCBI Official Full Name
cell adhesion molecule 3 isoform 1
NCBI Official Synonym Full Names
cell adhesion molecule 3
NCBI Official Symbol
CADM3
NCBI Official Synonym Symbols
BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3
NCBI Protein Information
cell adhesion molecule 3; TSLC1-like 1; nectin-like 1; TSLC1-like protein 1; nectin-like protein 1; brain immunoglobulin receptor; synaptic cell adhesion molecule 3; immunoglobulin superfamily member 4B; immunoglobulin superfamily, member 4B; dendritic cell nectin-like protein 1 short isoform
UniProt Protein Name
Cell adhesion molecule 3
Protein Family
UniProt Gene Name
CADM3
UniProt Synonym Gene Names
IGSF4B; NECL1; SYNCAM3; TSLL1; IgSF4B; NECL-1; SynCAM3; TSLL1
UniProt Entry Name
CADM3_HUMAN
NCBI Description
IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008]
Uniprot Description
CADM3: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 1q21.2-q22
Cellular Component: integral to membrane; plasma membrane; intercellular junction
Molecular Function: protein homodimerization activity
Biological Process: heterophilic cell adhesion; intercellular junction assembly and maintenance; protein localization; homophilic cell adhesion
Research Articles on CADM3
Similar Products
Product Notes
The CADM3 cadm3 (Catalog #AAA153452) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CADM3 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CADM3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). CADM3 antibody can be used for detection of CADM3 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the CADM3 cadm3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CADM3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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