Western Blot (WB)
(Western blot analysis of NLGN2 in rat brain tissue lysate with NLGN2 antibody at (A) 1 and (B) 2 μg/ml.)
Rabbit NLGN2 Polyclonal Antibody | anti-NLGN2 antibody
NLGN2 Antibody
Western Blot (WB)
(Western blot analysis of NLGN2 in rat brain tissue lysate with NLGN2 antibody at (A) 1 and (B) 2 μg/ml.)
Western Blot (WB)
(Western blot analysis of NLGN2 in rat brain tissue lysate with NLGN2 antibody at (A) 1 and (B) 2 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of NLGN2 in mouse brain tissue with NLGN2 antibody at 5 μg/ml.)
Immunohistochemistry (IHC)
(Immunohistochemistry of NLGN2 in mouse brain tissue with NLGN2 antibody at 5 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of NLGN2 in mouse brain tissue with NLGN2 antibody at 20 μg/ml.)
Immunofluorescence (IF)
(Immunofluorescence of NLGN2 in mouse brain tissue with NLGN2 antibody at 20 μg/ml.)
NCBI and Uniprot Product Information
Observed: 80; 97 kDa
NCBI Description
This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]
Uniprot Description
NLGN2: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma- aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion. Belongs to the type-B carboxylesterase/lipase family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: presynaptic membrane; extracellular space; postsynaptic membrane; cell surface; membrane; integral to plasma membrane; synapse; cell junction
Molecular Function: neurexin binding; cell adhesion molecule binding; receptor activity
Biological Process: regulation of synaptic transmission; positive regulation of synaptogenesis; cell-cell adhesion; synaptogenesis; metabolic process; positive regulation of synaptic transmission, GABAergic; synapse organization and biogenesis; neurological control of breathing; neuron adhesion; sensory perception of pain; neuromuscular process controlling balance; intercellular junction maintenance; positive regulation of synaptic transmission, glutamatergic
Research Articles on NLGN2
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Product Notes
The NLGN2 nlgn2 (Catalog #AAA153592) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The NLGN2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's NLGN2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). NLGN2 antibody can be used for detection of NLGN2 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL. Researchers should empirically determine the suitability of the NLGN2 nlgn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NLGN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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