Rabbit anti-Human, Mouse PAX-5 Monoclonal Antibody | anti-PAX-5 antibody

PAX-5 RMab

Cat. Num. AAA370098

• Gene Names: PAX5; BSAP
• Reactivity: Human, Mouse
• Synonyms: PAX-5; Monoclonal Antibody; PAX-5 RMab; anti-PAX-5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: RBT-PAX5
• Form/Format: PAX-5 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.

• Control: Tonsil
• Localization: Nuclear
• Reactivity Note: Paraffin, Frozen
• Preparation and Storage: Store at 2 to 8 degree C in the dark.

Dilution Information

Immunohistochemistry (IHC)

Related Product Information for anti-PAX-5 antibody

The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX-5 gene encodes the B-cell lineagespecific activator protein (BSAP) that is expressed at early, but not late, stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis; therefore, PAX-5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. PAX-5 expression is not only continuously required for B-cell lineage commitment during early B-cell development but also for B-cell lineage maintenance. PAX-5 is found in most cases of mature and precursor B-cell Non-Hodgkin's Lymphomas/Leukemias. PAX-5 is not detected in Multiple Myeloma and solitary Plasmacytoma, making it useful for such differentiation. Diffuse Large B-cell Lymphomas do express PAX-5, except for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5; however, there is a strong association with CD20 expression.

NCBI and Uniprot Product Information

• NCBI GI #: 417449
• NCBI GeneID: 5079
• NCBI Accession #: Q02548.1
• NCBI GenBank Nucleotide #: Q02548
• UniProt Accession #: Q02548; O75933; A3QVP6; A3QVP7; A3QVP8; Q6S728; Q6S729; Q6S730; Q6S731; Q6S732; Q93057; Q9BXX4
• Molecular Weight: 42,149 Da
• NCBI Official Full Name: Paired box protein Pax-5
• NCBI Official Synonym Full Names: paired box 5
• NCBI Official Symbol: PAX5
• NCBI Official Synonym Symbols: BSAP
• NCBI Protein Information: paired box protein Pax-5; OTTHUMP00000021378; OTTHUMP00000227118; OTTHUMP00000227119; OTTHUMP00000227120; OTTHUMP00000227121; OTTHUMP00000227122; OTTHUMP00000227123; OTTHUMP00000227124; OTTHUMP00000227125; OTTHUMP00000227127; OTTHUMP00000227128; OTTHUMP00000227129; paired box homeotic gene 5; transcription factor PAX 5; B cell specific activator protein; B-cell lineage specific activator; B-cell-specific transcription factor
• UniProt Protein Name: Paired box protein Pax-5
• UniProt Gene Name: PAX5
• UniProt Entry Name: PAX5_HUMAN

NCBI Description

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq]

Uniprot Description

Function: May play an important role in B-cell differentiation as well as neural development and spermatogenesis. Involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

Subunit structure: Interacts with DAXX

By similarity. Binds DNA as a monomer. Binds TLE4. Ref.4

Subcellular location: Nucleus.

Developmental stage: Expressed at early B-cell differentiation, in the developing CNS and in adult testis.

Post-translational modification: O-glycosylated

Probable.

Involvement in disease: Note=A chromosomal aberration involving PAX5 is a cause of acute lymphoblastic leukemia. Translocation t(9;18)(p13;q11.2) with ZNF521. Translocation t(9;3)(p13;p14.1) with FOXP1. Translocation t(9;12)(p13;p13) with ETV6.

Sequence similarities: Contains 1 paired domain.