Testing Data
Human Glutaminase (GLS1) Assay Kit
Glutaminase (GLS1) Inhibitor Screening Kit (Fluorometric)
Reactivity
Human
Synonyms
Glutaminase (GLS1); Glutaminase (GLS1) Inhibitor Screening Kit (Fluorometric); GLS1; GLS; GLS2; Glutaminase; Glutaminase (GLS1) assay kit
Reactivity
Human
Detection Method
Fluorometric: Ex/Em 535/587nm
Features & Benefits
Sensitive, specific assay for screening GLS1 inhibitors, Includes hrGLS1 and CB-839 (inhibitor control)
Screening of potential inhibitors of Glutaminase
Screening of potential inhibitors of Glutaminase
Preparation and Storage
Store at -20 degree C
Shelf life: ~12 months
Shelf life: ~12 months
Testing Data
Testing Data
Testing Data
Testing Data
Related Product Information for Glutaminase (GLS1) assay kit
Glutaminase (EC 3.5.1.2, GLS) is an enzyme that hydrolyzes glutamine producing glutamate and ammonia. It has tissue-specific roles in multiple organs, some of which include ammonia generation for urea synthesis in the liver; maintenance of acid-base homeostasis by ammonia production during renal acidosis in the kidney; and regulation of neurotransmitter glutamate in the brain. The isoform glutaminase 1 (GLS1) or phosphate-activated mitochondrial glutaminase is critical for glutamine utilization by cancer cells and the rate of glutaminolysis is known to increase in tumors, making it extremely important for tumor cell metabolism. GLS1 inhibitors have been considered as potential candidate drugs for cancer therapy. Glutaminase (GLS1) Inhibitor Screening Kit is a plate-based fluorometric kit for screening human GLS1 inhibitors. The hydrolysis of glutamine by glutaminase forms glutamate and ammonia. Glutamate, in the presence of a developer and enzyme mix, converts a non-fluorescent probe to a fluorescent product via an enzymatic reaction. A well-known Glutaminase inhibitor - CB-839 is provided as an inhibitor control.
Product Categories/Family for Glutaminase (GLS1) assay kit
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Product Notes
The Human Glutaminase (GLS1) (Catalog #AAA849696) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA849696 Assay Kit recognizes Human Glutaminase (GLS1). It is sometimes possible for the material contained within the vial of "Glutaminase (GLS1), Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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