Testing Data
Human Aldehyde Dehydrogenase 2 Assay Kit
Aldehyde Dehydrogenase 2 Inhibitor Screening Kit (Fluorometric)
Reactivity
Human
Synonyms
Aldehyde Dehydrogenase 2; Aldehyde Dehydrogenase 2 Inhibitor Screening Kit (Fluorometric); Aldehyde Dehydrogenase 2 assay kit
Reactivity
Human
Specificity
For screening; studying and characterizing potential inhibitors of ALDH2
Detection Method
Fluorescence at Ex/Em = 535/587nM
Features & Benefits
A quick and sensitive way of screening. Studying and characterizing potential inhibitors of ALDH2
Preparation and Storage
Store at -20 degree C
Shipping: Gel Pack
Shelf Life: Est.~12 months
Shipping: Gel Pack
Shelf Life: Est.~12 months
Testing Data
Testing Data
Related Product Information for Aldehyde Dehydrogenase 2 assay kit
Aldehyde Dehydrogenase 2 (ALDH2), mitochondrial is a member of the ALDH superfamily that participates in multiple metabolic pathways including the oxidation of toxic biogenic and environmental aldehydes. ALDH2 is a key enzyme located in the mitochondrial matrix. It plays an important role in ethanol metabolism by converting acetaldehyde, a carcinogenic metabolite of ethanol to acetate. Imbalances of ALDH2 have been linked to both alcoholism and alcohol sensitivity in people. Reduced ALDH2 activity has been strongly correlated with reduced alcohol consumption and reduced incidences of alcoholism, which led to the development of selective ALDH2 inhibitors as antidipsotropic or alcohol aversive agents for treating alcoholism. Disulfiram, an alcohol-aversive drug inhibiting ALDH2 has been approved by the FDA and is used clinically for over 40 years for treating alcohol dependency. However, the drug is a non-specific alkylating agent leading to many adverse side effects and drug-drug interactions. Thus, novel and specific inhibitors of ALDH2 free of the negative side effects could be used in aversion therapy. Aldehyde Dehydrogenase 2 Inhibitor Screening Kit provides a quick and sensitive way of screening, studying and characterizing potential inhibitors of ALDH2. In this assay, acetaldehyde is oxidized by ALDH2 to form NADH, which then couples with PicoProbe to generate a fluorescence signal measured at Ex/Em = 535/587nM. The percentage inhibition can be determined by comparing the activity of ALDH2 treated with test inhibitor(s) vs untreated control.
Product Categories/Family for Aldehyde Dehydrogenase 2 assay kit
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Product Notes
The Human Aldehyde Dehydrogenase 2 (Catalog #AAA8400617) is an Assay Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA8400617 Assay Kit recognizes Human Aldehyde Dehydrogenase 2. It is sometimes possible for the material contained within the vial of "Aldehyde Dehydrogenase 2, Assay Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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