General Plasminogen Activator-1 Assay Kit

Plasminogen Activator Inhibitor-1 Activity Assay Kit (C)

Cat. Num. AAA8400622

• Reactivity: General
• Synonyms: Plasminogen Activator-1; Plasminogen Activator Inhibitor-1 Activity Assay Kit (C); Plasminogen Activator-1 assay kit

• Reactivity: General
• Specificity: Measurement of PAI-1 activity in Biological Samples such as plasma; cell culture medium. Can detect as low as 2 U/ml of PAI-1 activity in samples. Analysis and study of fibrinolytic system

• Detection Method: Absorbance, OD 450nM
• Sample Type: Plasma, Cell and tissue culture supernatants
• Features & Benefits: Specific. Simple
• Preparation and Storage: Store at -20 degree C; Shipping: Gel Pack; Shelf Life: Est.~12 months

Testing Data

Related Product Information for Plasminogen Activator-1 assay kit

Plasminogen Activator Inhibitor-1 (PAI-1), also known as endothelial plasminogen activator inhibitor is a serine protease inhibitor that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA). PAI-1 is present in a number of tissues & cell types and is associated with various thrombotic and fibronolytic complications. High levels of PAI-1 activities are found in patients suffering from myocardial infarction, hemolytic uremic syndrome or stroke whereas low levels of PAI-1 activity are associated with bleeding disorders. Additionally, PAI-1 is a prognosticator in various cancers. Plasminogen Activator Inhibitor-1 Activity Assay Kit is a two-step colorimetric assay. In the first step, samples are incubated with a known amount of tPA thereby allowing PAI-1 and tPA to form an inactive complex. In the second step, the residual tPA converts plasminogen to plasmin, which in turn hydrolyzes the plasmin chromogenic substrate thereby releasing pNA (chromophore). The absorbance of the released pNA is inversely proportional to the PAI-1 activity in the samples. The assay kit is simple, specific and can detect as low as 2 U/ml of PAI-1 activity in samples.

Product Categories/Family for Plasminogen Activator-1 assay kit

Web Categories; Cardiovascular Research; Ischemia Reperfusion Injury; Assay Kits; Myocardial Infarction; Atherosclerosis; Hypertension; Diabetes; Obesity & Metabolic Syndrome; Arrhythmia & Cardiac Arrest; Renal Injury/Kidney Disease; Diabetes and Obesity;