Dilution Information
Rabbit FOXL2 Polyclonal Antibody | anti-FOXL2 antibody
FOXL2 (RPab)
Reactivity
Human, Mouse, Pig, Bovine
Synonyms
FOXL2; Polyclonal Antibody; FOXL2 (RPab); foxl2; anti-foxl2; forkhead box l2; anti-forkhead box l2; fox-l2; anti-fox-l2; fox l2; anti-fox l2; forkhead box protein L2; forkhead transcription factor FOXL2; PFRK; PINTO; POF3; anti-FOXL2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Pig, Bovine
Clonality
Polyclonal
Isotype
IgG
Form/Format
Paraffin, Frozen
FOXL2 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
FOXL2 is a rabbit polyclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to the C-terminus residues of the human FOXL2 protein.
Control
Fallopian Tube, Cervix, Pancreas, Placenta, Extra Marginal Zone Lymphoma
Localization
Cytoplasmic, Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
Dilution Information
Dilution Information
Immunohistochemistry (IHC)
(FOXL2 Antibody Immunohistochemistry on an FFPE Fallopian Tube Tissue)
Immunohistochemistry (IHC)
(FOXL2 Antibody Immunohistochemistry on an FFPE Fallopian Tube Tissue)
Related Product Information for anti-FOXL2 antibody
The Forkhead box L2 (FOXL2) gene encodes FOXL2, a transcription factor involved in ovarian development and function. Before birth and in adulthood, the FOXL2 protein regulates the growth and proliferation of hormone-producing ovarian granulosa cells. FOXL2 is also involved in the breakdown of fats, steroid hormones, and potentially harmful reactive oxygen species in the ovaries.
FOXL2 antibody is a relatively sensitive and highly specific marker for Sex Cord-Stromal Tumors (SCST). FOXL2 antibody expression is present in almost all SCSTs with a FOXL2 mutation or without a mutation. A specific somatic mutation in the FOXL2 gene has been found in Adult Granulosa Cell Tumor (402C-->G/C134W), which is present in 70-95% of Ovarian Adult Granulosa Cell Tumors but not in Ovarian Fibromas. This mutation is also present in 2 of 5 men with Adult Granulosa Cell Tumor but absent in Ovarian Juvenile Granulosa Cell Tumors. Studies have demonstrated that FOXL2 is expressed in Cervical Squamous Cancer. FOXL2 suppresses the proliferation and promotes apoptosis of Cervical Cancer cells mainly through decreasing Ki-67 expression and increasing Fas ligand expression. FOXL2 has also been found to restrain the invasiveness of Cervical Cancer cells; hence, FOXL2 might be a novel tumor suppressor in Cervical Cancer. A study has demonstrated that FOXL2 antibody is expressed in Breast Cancer and influences clinical outcome with improved recurrence-free survival in cases with nuclear expression. In a multivariate Cox model, nuclear FOXL2 was a significant prognostic factor in ER-positive patients treated with tamoxifen and tumors expressing nuclear FOXL2 were also more likely positive for stromal and/or cytoplasmic aromatase.
FOXL2 antibody is a relatively sensitive and highly specific marker for Sex Cord-Stromal Tumors (SCST). FOXL2 antibody expression is present in almost all SCSTs with a FOXL2 mutation or without a mutation. A specific somatic mutation in the FOXL2 gene has been found in Adult Granulosa Cell Tumor (402C-->G/C134W), which is present in 70-95% of Ovarian Adult Granulosa Cell Tumors but not in Ovarian Fibromas. This mutation is also present in 2 of 5 men with Adult Granulosa Cell Tumor but absent in Ovarian Juvenile Granulosa Cell Tumors. Studies have demonstrated that FOXL2 is expressed in Cervical Squamous Cancer. FOXL2 suppresses the proliferation and promotes apoptosis of Cervical Cancer cells mainly through decreasing Ki-67 expression and increasing Fas ligand expression. FOXL2 has also been found to restrain the invasiveness of Cervical Cancer cells; hence, FOXL2 might be a novel tumor suppressor in Cervical Cancer. A study has demonstrated that FOXL2 antibody is expressed in Breast Cancer and influences clinical outcome with improved recurrence-free survival in cases with nuclear expression. In a multivariate Cox model, nuclear FOXL2 was a significant prognostic factor in ER-positive patients treated with tamoxifen and tumors expressing nuclear FOXL2 were also more likely positive for stromal and/or cytoplasmic aromatase.
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Product Notes
The FOXL2 (Catalog #AAA370491) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FOXL2 (RPab) reacts with Human, Mouse, Pig, Bovine and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "FOXL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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