Rabbit DPR2 / DACT2 Polyclonal Antibody | anti-DPR2 antibody

Rabbit Polyclonal to Human DPR2 / DACT2

Cat. Num. AAA243370

• Gene Names: DACT2; DPR2; DAPPER2; C6orf116; bA503C24.7
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: DPR2 / DACT2; Polyclonal Antibody; Rabbit Polyclonal to Human DPR2 / DACT2; Anti-DPR2 / DACT2 Antibody (N-Terminus) IHC-plus; DACT2; BA503C24.7; DPR2; RP11-503C24.7; C6orf116; Dapper homolog 2; DAPPER2; Human DPR2; anti-DPR2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: At least two isoforms of Dact2 are known to exist.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS containing 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 774

• Applicable Applications for anti-DPR2 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
• Target Species: Human
• Immunogen Description: A 12 amino acid peptide from near the amino terminus of human DACT2.
• Immunogen Type: Synthetic peptide
• Immunogen: DPR2 / DACT2 antibody was raised against a 12 amino acid peptide from near the amino terminus of human DACT2.
• Antigen Modification: N-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-DACT2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-DACT2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of Dact2 in Human Brain cells with Dact2 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 163965434
• NCBI GeneID: 168002
• NCBI Accession #: NP_999627.2
• NCBI GenBank Nucleotide #: NM_214462.4
• UniProt Accession #: Q5SW24; Q2NKJ2; Q569G0; Q8WYW2
• Molecular Weight: 29,350 Da
• NCBI Official Full Name: dapper homolog 2 isoform a
• NCBI Official Synonym Full Names: dishevelled-binding antagonist of beta-catenin 2
• NCBI Official Symbol: DACT2
• NCBI Official Synonym Symbols: DPR2; DAPPER2; C6orf116; bA503C24.7
• NCBI Protein Information: dapper homolog 2; dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2
• UniProt Protein Name: Dapper homolog 2
• UniProt Gene Name: DACT2
• UniProt Synonym Gene Names: C6orf116
• UniProt Entry Name: DACT2_HUMAN

Uniprot Description

DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion

Molecular Function: protein kinase C binding; protein kinase A binding; beta-catenin binding; transcription factor binding

Biological Process: skin development; hemopoietic progenitor cell differentiation; negative regulation of cell adhesion