Rabbit anti-Human DACT2 Polyclonal Antibody | anti-DACT2 antibody

DACT2, NT (Dapper homolog 2, C6orf116, PP13671)

Cat. Num. AAA6011148

• Gene Names: DACT2; DPR2; DAPPER2; C6orf116; bA503C24.7; RP11-503C24.7
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: DACT2; Polyclonal Antibody; NT (Dapper homolog 2; C6orf116; PP13671); Anti -DACT2; anti-DACT2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human DACT2. Species sequence homology: Mouse, rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-DACT2 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 1-2ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 12aa from near the N-terminus of human DACT2.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of Dact2 in SK-N-SH cell lysate with Dact2 antibody at 1ug/ml)

Product Categories/Family for anti-DACT2 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 163965434
• NCBI GeneID: 168002
• NCBI Accession #: NP_999627.2
• NCBI GenBank Nucleotide #: NM_214462.3
• UniProt Accession #: Q5SW24; Q2NKJ2; Q569G0; Q8WYW2
• Molecular Weight: 82,700 Da
• NCBI Official Full Name: dapper homolog 2
• NCBI Official Synonym Full Names: dishevelled-binding antagonist of beta-catenin 2
• NCBI Official Symbol: DACT2
• NCBI Official Synonym Symbols: DPR2; DAPPER2; C6orf116; bA503C24.7; RP11-503C24.7
• NCBI Protein Information: dapper homolog 2; dapper antagonist of catenin 2; dapper homolog 2, antagonist of beta-catenin; dapper, antagonist of beta-catenin, homolog 2
• UniProt Protein Name: Dapper homolog 2
• Protein Family: Dapper
• UniProt Gene Name: DACT2
• UniProt Synonym Gene Names: C6orf116
• UniProt Entry Name: DACT2_HUMAN

Uniprot Description

DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: mitochondrion

Molecular Function: protein kinase C binding; protein kinase A binding; beta-catenin binding; transcription factor binding

Biological Process: skin development; hemopoietic progenitor cell differentiation; negative regulation of cell adhesion