Rabbit anti-Mouse, Rat GABRA5 Polyclonal Antibody | anti-GABRA5 antibody

GABRA5 Polyclonal Antibody

Cat. Num. AAA9130118

• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity purification
• Synonyms: GABRA5; Polyclonal Antibody; GABRA5 Polyclonal Antibody ; anti-GABRA5 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 462

• Applicable Applications for anti-GABRA5 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000 - 1:4000
• Immunogen: Recombinant protein of human GABRA5
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using GABRA5 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit.Exposure time: 3s.)

Product Categories/Family for anti-GABRA5 antibody

Polyclonal

NCBI and Uniprot Product Information

• NCBI GI #: 4503861
• NCBI GeneID: 2558
• NCBI Accession #: NP_000801.1
• NCBI GenBank Nucleotide #: NM_000810.3
• UniProt Accession #: P31644; Q14DC2; Q53XL6; Q9NYT3; Q9NYT4; Q9NYT5; A8K338; AAB22608
• Molecular Weight: Calculated MW: 52kDa; Molecular Weight: 462
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit alpha-5
• NCBI Official Synonym Full Names: gamma-aminobutyric acid type A receptor alpha5 subunit
• NCBI Official Symbol: GABRA5
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit alpha-5
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit alpha-5
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRA5
• UniProt Entry Name: GBRA5_HUMAN

NCBI Description

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

GABRA5: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA5 sub-subfamily.

Protein type: Transporter; Membrane protein, integral; Transporter, ion channel; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q12

Cellular Component: cell junction; dendrite; integral to plasma membrane; plasma membrane; postsynaptic membrane

Molecular Function: chloride channel activity; extracellular ligand-gated ion channel activity; GABA receptor binding; GABA-A receptor activity; receptor activity; transporter activity

Biological Process: associative learning; behavioral fear response; brain development; gamma-aminobutyric acid signaling pathway; inner ear receptor cell development; negative regulation of neuron apoptosis; positive regulation of defense response to virus by host; sensory perception of sound; signal transduction; synaptic transmission; transmembrane transport; transport