Western Blot (WB)
(Western Blot|Detection of Human Kynureninase by Western Blot. Western blot shows lysates of human liver tissue and A549 human lung carcinoma cell line. PVDF membrane was probed with 2ug/ml of Mouse Anti Human Kynureninase Monoclonal Antibody followed by HRP-conjugated Mouse IgG Secondary Antibody. A specific band was detected for Kynureninase at approximately 52kD. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.)
Mouse anti-Human Kynureninase Monoclonal Antibody | anti-Kynu antibody
Kynureninase (L-kynurenine Hydrolase, KYNU)
Purified by Protein A/G affinity chromatography.
Purified by Protein A/G affinity chromatography.
Dilution: Western Blot: 2ug/ml
Western Blot (WB)
(Western Blot|Detection of Human Kynureninase by Western Blot. Western blot shows lysates of human liver tissue and A549 human lung carcinoma cell line. PVDF membrane was probed with 2ug/ml of Mouse Anti Human Kynureninase Monoclonal Antibody followed by HRP-conjugated Mouse IgG Secondary Antibody. A specific band was detected for Kynureninase at approximately 52kD. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.)
Western Blot (WB)
(Western Blot|Detection of Human Kynureninase by Western Blot. Western blot shows lysates of human liver tissue and A549 human lung carcinoma cell line. PVDF membrane was probed with 2ug/ml of Mouse Anti Human Kynureninase Monoclonal Antibody followed by HRP-conjugated Mouse IgG Secondary Antibody. A specific band was detected for Kynureninase at approximately 52kD. This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.)
NCBI and Uniprot Product Information
NCBI Description
enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006]
Uniprot Description
KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Hydrolase; Amino Acid Metabolism - tryptophan; EC 3.7.1.3
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol
Molecular Function: protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding
Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process
Research Articles on Kynu
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Product Notes
The Kynu kynu (Catalog #AAA641672) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Kynureninase (L-kynurenine Hydrolase, KYNU) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Kynureninase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 2ug/ml. Researchers should empirically determine the suitability of the Kynu kynu for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Kynureninase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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