Testing Data
KW 2449, inhibitor
KW 2449
Synonyms
KW 2449; inhibitor
Solubility
DMSO >=67 mg/mL - Water <1 mg/mL - Ethanol >=67 mg/mL
Formula
C20H20N4O
CAS Number
1000669-72-6
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for KW 2449, inhibitor
KW-2449, a multi-kinase inhibitor of FLT3(IC50 at 6.6pM), ABL(IC50 at 14pM), ABL-T315I and Aurora kinase, is under investigation to treat leukemia patients. KW-2449 potently and selectively inhibits the growth of leukemia cells harboring constitutively activated FLT3 kinase both in vitro and in vivo. In addition, it potently inhibitedABL-T315I, which is associated with IM resistance, with an IC50 value of 4 pM. On the other hand, KW-2449 had little effect on PDGFR, IGF-I R, EGFR, and various serine/threonine kinases even at a concentration of 1 uM. Among various serine/threonine kinases examined, KW-2449 inhibited Aurora A kinase with IC50 of 48 pMp and Aurora B kinase with the equivalent potenc. [1, 2]
Product Categories/Family for KW 2449, inhibitor
References
KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation Yukimasa Shiotsu, Hitoshi Kiyoi, et al. Blood 2009; 114: 1607-1617 A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response Keith W. Pratz, Jorge Cortes, et al. Blood 2009; 113: 3938-3946 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Similar Products
Product Notes
The KW 2449 (Catalog #AAA8506465) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "KW 2449, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
