Testing Data
JNJ-7706621, inhibitor
JNJ-7706621
Synonyms
JNJ-7706621; inhibitor
Solubility
DMSO >=79 mg/mL - Water <1 mg/mL - Ethanol >=3 mg/mL
Formula
C15H12F2N6O3S
CAS Number
443797-96-4
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for JNJ-7706621, inhibitor
JNJ-7706621 is a dual cyclin-dependent kinases and aurora kinases inhibitor with IC50 of 9 and 11 nM for CDK1/Cyclin B and aurora-A, respectively. JNJ-7706621 blocked proliferation of cancer cells regardless of their p53, retinoblastoma or P-glycoprotein status and induced cell death by activating apoptosis. JNJ-7706621 was about 10 fold less effective at inhibiting proliferation of normal cells. Flow cytometric analysis of DNA content in human tumor cells showed that JNJ-7706621 delayed progression through G1 and arrested the cell cycle at the G2/M phase. JNJ-7706621 also decreased CDK1 kinase activity, altered CDK1 phosphorylation status and blocked signaling to downstream substrates of CDKs. Additional cellular effects including endoreduplication and reduced histone H3 phosphorylation were also observed due to inhibition of Aurora kinase. JNJ-7706621 demonstrated significant inhibition of tumor growth in a variety of tumor types in nude mice xenograft models. In vitro cell proliferation assays IC50 (muM): HeLa (IC50=0.286), HCT-116 (IC50=0.189), PC3 (IC50=0.112). JNJ-7706621 is not affected by P-glycoprotein. [1][2][3]
Product Categories/Family for JNJ-7706621, inhibitor
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Product Notes
The JNJ-7706621 (Catalog #AAA8506369) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "JNJ-7706621, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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