Testing Data
Saracatinib, Inhibitor
Saracatinib (AZD0530)
Purity
>99%
Synonyms
Saracatinib; Saracatinib (AZD0530); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=108mg/mL - Water <1mg/mL - Ethanol >=108mg/mL
Formula
C27H32ClN5O5
CAS Number
379231-04-6
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Saracatinib, inhibitor
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Saracatinib (AZD0530) a novel anilino quinazoline. AZD0530(Saracatinib) is highly selective for Src and Abl kinases against a large range of tyrosine and serine-threonine kinases (VEGFR2, FGFR, c-Kit, Aur-3 etc. >5 uM). Saracatinib (AZD0530) exerts its activity through ATP competitive and reversible inhibition of the target enzyme. Saracatinib (AZD0530) potently inhibited the in vitro proliferation of Src3T3 mouse fibroblasts and demonstrated variable antiproliferative activity in a range of human cancer cell lines containing endogenous Src. Sub micromolar growth inhibition of five of the human cancer cell lines tested with saracatinib (AZD0530) was observed with IC50 values of 0.2~0.7 uM. In 3-day MTS cell proliferation assays, Saracatinib (AZD0530) inhibited in vitro proliferation of the Bcr-Abl-driven human leukemia cell line K562 with an IC50 of 0.22 uM. In a head-to-head assay measuring EGFR phosphorylation in KB cells, Saracatinib (AZD0530) exhibited an IC50 of 1.25 mM compared with 11 nM for gefitinib. [1][2]
Product Categories/Family for Saracatinib, inhibitor
Similar Products
Product Notes
The Saracatinib (Catalog #AAA8506571) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Saracatinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
